Literature DB >> 33012428

The Molecular Basis of Malignant Pleural Mesothelioma.

Benjamin Wadowski1, Assunta De Rienzo1, Raphael Bueno2.   

Abstract

Malignant pleural mesothelioma (MPM) is a rare, aggressive malignancy of the pleural lining associated with asbestos exposure in greater than 80% of cases. It is characterized by molecular heterogeneity both between patients and within individual tumors. Next-generation sequencing technology and novel computational techniques have resulted in a greater understanding of the epigenetic, genetic, and transcriptomic hallmarks of MPM. This article reviews these features and discusses the implications of advances in MPM molecular biology in clinical practice.
Copyright © 2020 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Epigenetic; Gene expression; Genetic; Mesothelioma; Molecular

Mesh：

Substances：

Year:  2020        PMID： 33012428      PMCID： PMC7536355          DOI： 10.1016/j.thorsurg.2020.08.005

Source DB:  PubMed          Journal:  Thorac Surg Clin            Impact factor:   1.750


  86 in total

1.  Differential gene expression in mesothelioma.

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Journal:  FEBS Lett       Date:  2000-09-01       Impact factor: 4.124

Review 2.  The role of apoptosis defects in malignant mesothelioma pathogenesis with an impact on prognosis and treatment.

Authors:  Vasiliki Galani; Anna Varouktsi; Stamatis S Papadatos; Antigoni Mitselou; Ioannis Sainis; Stavros Constantopoulos; Yotanna Dalavanga
Journal:  Cancer Chemother Pharmacol       Date:  2019-05-22       Impact factor: 3.333

Review 3.  The Use of Radiation Therapy for the Treatment of Malignant Pleural Mesothelioma: Expert Opinion from the National Cancer Institute Thoracic Malignancy Steering Committee, International Association for the Study of Lung Cancer, and Mesothelioma Applied Research Foundation.

Authors:  Daniel R Gomez; Andreas Rimner; Charles B Simone; B C John Cho; Marc de Perrot; Alex A Adjei; Raphael Bueno; Ritu R Gill; David H Harpole; Mary Hesdorffer; Fred R Hirsch; Andrew A Jackson; Harvey I Pass; David C Rice; Valerie W Rusch; Anne S Tsao; Ellen Yorke; Kenneth Rosenzweig
Journal:  J Thorac Oncol       Date:  2019-05-22       Impact factor: 15.609

4.  Co-occurring Mutations of Tumor Suppressor Genes, LATS2 and NF2, in Malignant Pleural Mesothelioma.

Authors:  Robin Tranchant; Lisa Quetel; Anne Tallet; Clement Meiller; Annie Renier; Leanne de Koning; Aurelien de Reynies; Francoise Le Pimpec-Barthes; Jessica Zucman-Rossi; Marie-Claude Jaurand; Didier Jean
Journal:  Clin Cancer Res       Date:  2016-12-21       Impact factor: 12.531

5.  Validation of genomics-based prognostic tests in malignant pleural mesothelioma.

Authors:  Gavin J Gordon; Graham N Rockwell; Paul A Godfrey; Roderick V Jensen; Jonathan N Glickman; Beow Y Yeap; William G Richards; David J Sugarbaker; Raphael Bueno
Journal:  Clin Cancer Res       Date:  2005-06-15       Impact factor: 12.531

6.  Identification of novel candidate oncogenes and tumor suppressors in malignant pleural mesothelioma using large-scale transcriptional profiling.

Authors:  Gavin J Gordon; Graham N Rockwell; Roderick V Jensen; James G Rheinwald; Jonathan N Glickman; Joshua P Aronson; Brian J Pottorf; Matthew D Nitz; William G Richards; David J Sugarbaker; Raphael Bueno
Journal:  Am J Pathol       Date:  2005-06       Impact factor: 4.307

7.  Global gene expression profiling of pleural mesotheliomas: overexpression of aurora kinases and P16/CDKN2A deletion as prognostic factors and critical evaluation of microarray-based prognostic prediction.

Authors:  Fernando López-Ríos; Shannon Chuai; Raja Flores; Shigeki Shimizu; Takatoshi Ohno; Kazuhiko Wakahara; Peter B Illei; Sanaa Hussain; Lee Krug; Maureen F Zakowski; Valerie Rusch; Adam B Olshen; Marc Ladanyi
Journal:  Cancer Res       Date:  2006-03-15       Impact factor: 12.701

Review 8.  The Genetic Landscape of Malignant Pleural Mesothelioma: Results from Massively Parallel Sequencing.

Authors:  Marieke Hylebos; Guy Van Camp; Jan P van Meerbeeck; Ken Op de Beeck
Journal:  J Thorac Oncol       Date:  2016-06-06       Impact factor: 15.609

9.  BAP1 cancer syndrome: malignant mesothelioma, uveal and cutaneous melanoma, and MBAITs.

Authors:  Michele Carbone; Laura Korb Ferris; Francine Baumann; Andrea Napolitano; Christopher A Lum; Erin G Flores; Giovanni Gaudino; Amy Powers; Peter Bryant-Greenwood; Thomas Krausz; Elizabeth Hyjek; Rachael Tate; Joseph Friedberg; Tracey Weigel; Harvey I Pass; Haining Yang
Journal:  J Transl Med       Date:  2012-08-30       Impact factor: 5.531

10.  Loss of BAP1 function leads to EZH2-dependent transformation.

Authors:  Lindsay M LaFave; Wendy Béguelin; Richard Koche; Matt Teater; Barbara Spitzer; Alan Chramiec; Efthymia Papalexi; Matthew D Keller; Todd Hricik; Katerina Konstantinoff; Jean-Baptiste Micol; Benjamin Durham; Sarah K Knutson; John E Campbell; Gil Blum; Xinxu Shi; Emma H Doud; Andrei V Krivtsov; Young Rock Chung; Inna Khodos; Elisa de Stanchina; Ouathek Ouerfelli; Prasad S Adusumilli; Paul M Thomas; Neil L Kelleher; Minkui Luo; Heike Keilhack; Omar Abdel-Wahab; Ari Melnick; Scott A Armstrong; Ross L Levine
Journal:  Nat Med       Date:  2015-10-05       Impact factor: 53.440
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  6 in total

1.  G6PD functions as a metabolic checkpoint to regulate granzyme B expression in tumor-specific cytotoxic T lymphocytes.

Authors:  Chunwan Lu; Dafeng Yang; John D Klement; Yolonda L Colson; Nicholas H Oberlies; Cedric J Pearce; Aaron H Colby; Mark W Grinstaff; Han-Fei Ding; Huidong Shi; Kebin Liu
Journal:  J Immunother Cancer       Date:  2022-01       Impact factor: 13.751

2.  Molecular Radiotherapy with 177Lu-Immunoliposomes Induces Cytotoxicity in Mesothelioma Cancer Stem Cells In Vitro.

Authors:  Tao Huang; Jae Sam Lee; Alexander L Klibanov; Jiang He
Journal:  Int J Mol Sci       Date:  2022-04-01       Impact factor: 5.923

Review 3.  Molecular Mechanisms of Autophagy in Cancer Development, Progression, and Therapy.

Authors:  Veronica Angela Maria Vitto; Silvia Bianchin; Alicia Ann Zolondick; Giulia Pellielo; Alessandro Rimessi; Diego Chianese; Haining Yang; Michele Carbone; Paolo Pinton; Carlotta Giorgi; Simone Patergnani
Journal:  Biomedicines       Date:  2022-07-05

Review 4.  When the Diagnosis of Mesothelioma Challenges Textbooks and Guidelines.

Authors:  Giulio Rossi; Fabio Davoli; Venerino Poletti; Alberto Cavazza; Filippo Lococo
Journal:  J Clin Med       Date:  2021-05-30       Impact factor: 4.241

Review 5.  Tumor Immune Microenvironment and Genetic Alterations in Mesothelioma.

Authors:  Stefanie Hiltbrunner; Laura Mannarino; Michaela B Kirschner; Isabelle Opitz; Angelica Rigutto; Alexander Laure; Michela Lia; Paolo Nozza; Antonio Maconi; Sergio Marchini; Maurizio D'Incalci; Alessandra Curioni-Fontecedro; Federica Grosso
Journal:  Front Oncol       Date:  2021-06-23       Impact factor: 6.244

6.  Gene Expression Analysis of Biphasic Pleural Mesothelioma: New Potential Diagnostic and Prognostic Markers.

Authors:  Rossella Bruno; Anello Marcello Poma; Greta Alì; Claudia Distefano; Agnese Proietti; Antonio Chella; Marco Lucchi; Franca Melfi; Renato Franco; Gabriella Fontanini
Journal:  Diagnostics (Basel)       Date:  2022-03-10
  6 in total

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