Literature DB >> 33011905

Point-of-care multiplex-PCR enables germ identification in haemolytic uremic syndrome 94 h earlier than stool culture.

Luis Hernán Llano López1, Pablo Melonari2, Stephan Gehring3, Daniel Schreiner3, Sandra Grucci4, Sofía Pérez Araujo5, Lorena Di Pauli2, Christina Oetzmann von Sochaczewski6, Arne Schröder7, Laura Piovano8.   

Abstract

Haemolytic uremic syndrome often affects children causing a relevant morbidity and mortality. We compared the time to diagnosis by multiplex-PCR and stool culture in 15 children from two centres. Multiplex-PCR accelerated the time to diagnosis by 94 (95% confidence interval, 80-119; P = 0.0007) hours. Multiplex-PCR offers a time advantage of stool culture that may aid in earlier identification of outbreak clusters.

Entities:  

Keywords:  Biofire; Children; Gastrointestinal panel; Shiga-like toxin

Mesh：

Year:  2020        PMID： 33011905     DOI： 10.1007/s10096-020-04060-x

Source DB:  PubMed          Journal:  Eur J Clin Microbiol Infect Dis        ISSN： 0934-9723            Impact factor:   3.267


  8 in total

1.  Comparative Evaluation of Enteric Bacterial Culture and a Molecular Multiplex Syndromic Panel in Children with Acute Gastroenteritis.

Authors:  Thomas Kellner; Brendon Parsons; Linda Chui; Byron M Berenger; Jianling Xie; C A Burnham; Phillip I Tarr; Bonita E Lee; Alberto Nettel-Aguirre; Jonas Szelewicki; Otto G Vanderkooi; Xiao-Li Pang; Nathan Zelyas; Stephen B Freedman
Journal:  J Clin Microbiol       Date:  2019-05-24       Impact factor: 5.948

2.  Real-Time PCR Assay for Detection and Differentiation of Shiga Toxin-Producing Escherichia coli from Clinical Samples.

Authors:  Xuan Qin; Eileen J Klein; Emmanouil Galanakis; Anita A Thomas; Jennifer R Stapp; Shannon Rich; Anne Marie Buccat; Phillip I Tarr
Journal:  J Clin Microbiol       Date:  2015-04-29       Impact factor: 5.948

3.  Desperately seeking diarrhoea: outbreak of haemolytic uraemic syndrome caused by emerging sorbitol-fermenting shiga toxin-producing Escherichia coli O157:H-, Germany, 2009.

Authors:  S Nielsen; C Frank; A Fruth; A Spode; R Prager; A Graff; A Plenge-Bönig; S Loos; M Lütgehetmann; M J Kemper; D E Müller-Wiefel; D Werber
Journal:  Zoonoses Public Health       Date:  2011-04-06       Impact factor: 2.702

4.  Impact of Gastrointestinal Panel Implementation on Health Care Utilization and Outcomes.

Authors:  Jordan E Axelrad; Daniel E Freedberg; Susan Whittier; William Greendyke; Benjamin Lebwohl; Daniel A Green
Journal:  J Clin Microbiol       Date:  2019-02-27       Impact factor: 5.948

5.  A Gastrointestinal PCR Panel Improves Clinical Management and Lowers Health Care Costs.

Authors:  Stacy G Beal; Elizabeth E Tremblay; Steven Toffel; Lymaries Velez; Kenneth H Rand
Journal:  J Clin Microbiol       Date:  2017-12-26       Impact factor: 5.948

6.  Hemolytic uremic syndrome (HUS)--incidence and etiologies at a regional Children's Hospital in 2001-2006.

Authors:  R J Pomajzl; M Varman; A Holst; A Chen
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2009-08-16       Impact factor: 3.267

7.  Contribution of the FilmArray® Gastrointestinal Panel in the laboratory diagnosis of gastroenteritis in a cohort of children: a two-year prospective study.

Authors:  Adriana Calderaro; Monica Martinelli; Mirko Buttrini; Sara Montecchini; Silvia Covan; Sabina Rossi; Francesca Ferraglia; Paolo Montagna; Federica Pinardi; Sandra Larini; Maria Cristina Arcangeletti; Maria Cristina Medici; Carlo Chezzi; Flora De Conto
Journal:  Int J Med Microbiol       Date:  2018-05-02       Impact factor: 3.473

8.  Clinical and Laboratory Predictors of Shiga Toxin-Producing Escherichia coli Infection in Children With Bloody Diarrhea.

Authors:  Ryan S McKee; Phillip I Tarr; Dennis J Dietzen; Rachit Chawla; David Schnadower
Journal:  J Pediatric Infect Dis Soc       Date:  2018-08-17       Impact factor: 3.164
  8 in total
  1 in total

1.  Paediatric surgical trials, their fragility index, and why to avoid using it to evaluate results.

Authors:  Arne Schröder; Oliver J Muensterer; Christina Oetzmann von Sochaczewski
Journal:  Pediatr Surg Int       Date:  2022-05-07       Impact factor: 2.003
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.