| Literature DB >> 33011564 |
Guilherme M Nobrega1, Ana Paula Samogim2, Pierina L Parise2, Emanuella M Venceslau3, José Paulo S Guida3, Rodolfo R Japecanga3, Mariene R Amorim2, Daniel A Toledo-Teixeira2, Julia Forato2, Sílvio R Consonni4, Maria Laura Costa5, José Luiz Proenca-Modena6.
Abstract
To investigate the role of TYRO3, AXL and TIM1 receptors in the Zika virus (ZIKV) cycle, we determined their mRNA expression in different placental sites of ZIKV infected tissue during pregnancy. Unexpectedly, the ZIKV infection was not related with mRNA upregulation of these receptors or changes in expression of type I and III interferons in different placental sites. Instead, a decrease of TYRO3 mRNA expression was observed in positive sites of ZIKV positive placentas in comparison to negative sites. The basis of this downregulation can help to understand how ZIKV persists in placental tissue during pregnancy.Entities:
Keywords: Interferons; Placenta; TAM receptors; TIM receptors; Zika virus.; mRNA expression
Year: 2020 PMID： 33011564 DOI： 10.1016/j.placenta.2020.09.062
Source DB: PubMed Journal: Placenta ISSN： 0143-4004 Impact factor: 3.481