Ami Fukunaga1, Huan Hu2, Yosuke Inoue2, Tohru Nakagawa3, Toru Honda3, Shuichiro Yamamoto3, Toshiaki Miyamoto4, Hiroko Okazaki5, Makiko Shimizu6, Masafumi Eguchi7, Takeshi Kochi7, Makoto Yamamoto8, Takayuki Ogasawara9, Naoko Sasaki9, Akihiko Uehara10, Teppei Imai11, Akiko Nishihara12, Ai Hori13, Satsue Nagahama14, Kentaro Tomita15, Maki Konishi2, Isamu Kabe16, Tetsuya Mizoue2, Seitaro Dohi5. 1. Department of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan. Electronic address: afukunaga@hosp.ncgm.go.jp. 2. Department of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan. 3. Hitachi, Ltd., Ibaraki, Japan. 4. NIPPON STEEL CORPORATION, Chiba, Japan. 5. Mitsui Chemicals, Inc., Tokyo, Japan. 6. Mizue Medical Clinic, Keihin Occupational Health Center, Kanagawa, Japan. 7. Furukawa Electric Co., Ltd., Tokyo, Japan. 8. Yamaha Corporation, Shizuoka, Japan. 9. Mitsubishi Fuso Truck and Bus Corporation, Kanagawa, Japan. 10. Hidaka Tokushukai Hospital, Hokkaido, Japan. 11. OH Support Company, Kanagawa, Japan. 12. Azbil Corporation, Tokyo, Japan. 13. Department of Global Public Health, University of Tsukuba, Ibaraki, Japan. 14. All Japan Labour Welfare Foundation, Tokyo, Japan. 15. Healthplant Co., Ltd., Tokyo, Japan. 16. KUBOTA Corporation, Tokyo, Japan.
Abstract
OBJECTIVE: To examine the association of diabetes and prediabetes with suicide deaths in a Japanese working population. METHODS: A nested case-control study was conducted using data from the Japan Epidemiology Collaboration on Occupational Health Study. During 8 years of follow-up, we identified 56 registered cases of suicide death that had information on fasting plasma glucose or glycated hemoglobin A1c at any health check-up during the past 3 years prior to suicide. For each case, we randomly selected five controls matched for age, sex, and worksite. We used the latest health check-up data for analysis. We defined diabetes status based on the American Diabetes Association criteria and used a conditional logistic regression model to investigate the association. RESULTS: Adjusted odds ratios and 95% confidence intervals for suicide death were 0.67 (0.32-1.41) and 3.53 (1.05-11.91) for prediabetes and diabetes, respectively, compared to normoglycemia. Similar results were obtained when diabetes status was exclusively defined by the fasting plasma glucose or glycated hemoglobin A1c level. CONCLUSION: Diabetes, but not prediabetes, was associated with a higher risk of suicide death, compared with normoglycemia, among a Japanese working population.
OBJECTIVE: To examine the association of diabetes and prediabetes with suicide deaths in a Japanese working population. METHODS: A nested case-control study was conducted using data from the Japan Epidemiology Collaboration on Occupational Health Study. During 8 years of follow-up, we identified 56 registered cases of suicide death that had information on fasting plasma glucose or glycated hemoglobin A1c at any health check-up during the past 3 years prior to suicide. For each case, we randomly selected five controls matched for age, sex, and worksite. We used the latest health check-up data for analysis. We defined diabetes status based on the American Diabetes Association criteria and used a conditional logistic regression model to investigate the association. RESULTS: Adjusted odds ratios and 95% confidence intervals for suicide death were 0.67 (0.32-1.41) and 3.53 (1.05-11.91) for prediabetes and diabetes, respectively, compared to normoglycemia. Similar results were obtained when diabetes status was exclusively defined by the fasting plasma glucose or glycated hemoglobin A1c level. CONCLUSION:Diabetes, but not prediabetes, was associated with a higher risk of suicide death, compared with normoglycemia, among a Japanese working population.