Literature DB >> 33010477

Can easy chemistry produce complex, diverse, and novel molecules?

Anna Tomberg1, Jonas Boström2.   

Abstract

Easy-to-make compounds are often perceived to be inferior compared with molecules obtained through elaborate reaction schemes. This study evaluates in depths whether this perception is true.
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

Entities:  

Year:  2020        PMID： 33010477     DOI： 10.1016/j.drudis.2020.09.027

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  7 in total

1.  Uniting Amide Synthesis and Activation by PIII/PV-Catalyzed Serial Condensation: Three-Component Assembly of 2-Amidopyridines.

Authors:  Jeffrey M Lipshultz; Alexander T Radosevich
Journal:  J Am Chem Soc       Date:  2021-09-03       Impact factor: 16.383

2.  Comparison of structure- and ligand-based scoring functions for deep generative models: a GPCR case study.

Authors:  Morgan Thomas; Robert T Smith; Noel M O'Boyle; Chris de Graaf; Andreas Bender
Journal:  J Cheminform       Date:  2021-05-13       Impact factor: 5.514

3.  Amide Bond Formation via the Rearrangement of Nitrile Imines Derived from N-2-Nitrophenyl Hydrazonyl Bromides.

Authors:  Mhairi Boyle; Keith Livingstone; Martyn C Henry; Jessica M L Elwood; J Daniel Lopez-Fernandez; Craig Jamieson
Journal:  Org Lett       Date:  2021-12-29       Impact factor: 6.005

Review 4.  Defining Levels of Automated Chemical Design.

Authors:  Brian Goldman; Steven Kearnes; Trevor Kramer; Patrick Riley; W Patrick Walters
Journal:  J Med Chem       Date:  2022-05-05       Impact factor: 8.039

5.  MO-MEMES: A method for accelerating virtual screening using multi-objective Bayesian optimization.

Authors:  Sarvesh Mehta; Manan Goel; U Deva Priyakumar
Journal:  Front Med (Lausanne)       Date:  2022-09-23

6.  On drug discovery against infectious diseases and academic medicinal chemistry contributions.

Authors:  Yves L Janin
Journal:  Beilstein J Org Chem       Date:  2022-09-29       Impact factor: 2.544

7.  Generating Multibillion Chemical Space of Readily Accessible Screening Compounds.

Authors:  Oleksandr O Grygorenko; Dmytro S Radchenko; Igor Dziuba; Alexander Chuprina; Kateryna E Gubina; Yurii S Moroz
Journal:  iScience       Date:  2020-10-15
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.