| Literature DB >> 33010303 |
Ning Luo1, Jian Fang1, LiQin Wei1, Amirhossein Sahebkar2, Peter J Little3, Suowen Xu4, ChongBin Luo5, GuangNing Li6.
Abstract
Atherosclerotic plaque formation, destabilization and eventual rupture leads to the acute cardiovascular events including myocardial infarction and stroke. Emodin (PubChem CID#3220), (1,3,8-trihydroxy-6-methylanthracene-9,10-dione) is a pharmacologically bioactive constituent isolated from the traditional Chinese medicinal herb Radix rhizoma Rhei. This molecule has anti-oxidant, anti-inflammatory, anti-proliferative, anti-apoptotic and lipid-modulating effects. Experimental studies have demonstrated that emodin attenuates and stabilizes atherosclerotic plaques. In this mini-review, we provide a summary of the pharmacological actions of emodin in regulating vascular function and atherosclerosis, highlighting the therapeutic potential of this phytochemical in patients with cardiovascular disease.Entities:
Keywords: Atherosclerosis; Cardiovascular disease; Emodin; Therapeutic target
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Year: 2020 PMID： 33010303 DOI： 10.1016/j.ejphar.2020.173617
Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432