Literature DB >> 3301019

Efficient synthetic method for ethyl (+)-(2S,3S)-3-[(S)-3-methyl- 1-(3-methylbutylcarbamoyl)butylcarbamoyl]-2-oxiranecarb oxylate (EST), a new inhibitor of cysteine proteinases.

M Tamai, C Yokoo, M Murata, K Oguma, K Sota, E Sato, Y Kanaoka.   

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Year:  1987        PMID: 3301019

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN: 0009-2363            Impact factor:   1.645


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  11 in total

1.  The cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, β-secretase activity.

Authors:  Gregory Hook; Vivian Hook; Mark Kindy
Journal:  J Alzheimers Dis       Date:  2011       Impact factor: 4.472

2.  Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L.

Authors:  Erica N Parker; Jiangli Song; G D Kishore Kumar; Samuel O Odutola; Gustavo E Chavarria; Amanda K Charlton-Sevcik; Tracy E Strecker; Ashleigh L Barnes; Dhivya R Sudhan; Thomas R Wittenborn; Dietmar W Siemann; Michael R Horsman; David J Chaplin; Mary Lynn Trawick; Kevin G Pinney
Journal:  Bioorg Med Chem       Date:  2015-09-25       Impact factor: 3.641

3.  Proteolytic processing of Middle East respiratory syndrome coronavirus spikes expands virus tropism.

Authors:  Jung-Eun Park; Kun Li; Arlene Barlan; Anthony R Fehr; Stanley Perlman; Paul B McCray; Tom Gallagher
Journal:  Proc Natl Acad Sci U S A       Date:  2016-10-10       Impact factor: 11.205

4.  Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer.

Authors:  Kwang Woon Kim; Misun Hwang; Luigi Moretti; Jerry J Jaboin; Yong I Cha; Bo Lu
Journal:  Autophagy       Date:  2008-04-07       Impact factor: 16.016

5.  Inhibition of interleukin 1-stimulated cartilage proteoglycan degradation by a lipophilic inactivator of cysteine endopeptidases.

Authors:  D J Buttle; J Saklatvala; M Tamai; A J Barrett
Journal:  Biochem J       Date:  1992-01-01       Impact factor: 3.857

6.  Brain pyroglutamate amyloid-β is produced by cathepsin B and is reduced by the cysteine protease inhibitor E64d, representing a potential Alzheimer's disease therapeutic.

Authors:  Gregory Hook; Jin Yu; Thomas Toneff; Mark Kindy; Vivian Hook
Journal:  J Alzheimers Dis       Date:  2014       Impact factor: 4.472

7.  The cysteine protease cathepsin B is a key drug target and cysteine protease inhibitors are potential therapeutics for traumatic brain injury.

Authors:  Gregory R Hook; Jin Yu; Nancy Sipes; Michael D Pierschbacher; Vivian Hook; Mark S Kindy
Journal:  J Neurotrauma       Date:  2014-02-06       Impact factor: 5.269

8.  A programmed cell death pathway in the malaria parasite Plasmodium falciparum has general features of mammalian apoptosis but is mediated by clan CA cysteine proteases.

Authors:  J-H Ch'ng; S R Kotturi; A G-L Chong; M J Lear; K S-W Tan
Journal:  Cell Death Dis       Date:  2010       Impact factor: 8.469

9.  M-opsin protein degradation is inhibited by MG-132 in Rpe65⁻/⁻ retinal explant culture.

Authors:  Kota Sato; Taku Ozaki; Sei-ichi Ishiguro; Mitsuru Nakazawa
Journal:  Mol Vis       Date:  2012-06-13       Impact factor: 2.367

10.  A super-ecliptic, pHluorin-mKate2, tandem fluorescent protein-tagged human LC3 for the monitoring of mammalian autophagy.

Authors:  Isei Tanida; Takashi Ueno; Yasuo Uchiyama
Journal:  PLoS One       Date:  2014-10-23       Impact factor: 3.240

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