| Literature DB >> 33010154 |
Yingbo Cui1, Xiaolong Cheng2, Qing Chen2, Bicna Song2, Anthony Chiu2,3, Yuan Gao2,4, Tyson Dawson2,5,6, Lumen Chao2, Wubing Zhang7, Dian Li7, Zexiang Zeng7, Jijun Yu8, Zexu Li9, Teng Fei9, Shaoliang Peng10, Wei Li2,11.
Abstract
High-throughput genetic screening based on CRISPR/Cas9 or RNA-interference (RNAi) enables the exploration of genes associated with the phenotype of interest on a large scale. The rapid accumulation of public available genetic screening data provides a wealth of knowledge about genotype-to-phenotype relationships and a valuable resource for the systematic analysis of gene functions. Here we present CRISP-view, a comprehensive database of CRISPR/Cas9 and RNAi screening datasets that span multiple phenotypes, including in vitro and in vivo cell proliferation and viability, response to cancer immunotherapy, virus response, protein expression, etc. By 22 September 2020, CRISP-view has collected 10 321 human samples and 825 mouse samples from 167 papers. All the datasets have been curated, annotated, and processed by a standard MAGeCK-VISPR analysis pipeline with quality control (QC) metrics. We also developed a user-friendly webserver to visualize, explore, and search these datasets. The webserver is freely available at http://crispview.weililab.org.Entities:
Year: 2021 PMID： 33010154 PMCID： PMC7778972 DOI： 10.1093/nar/gkaa809
Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971