Jae Won Park1, Kyungdo Han2, Dong Wook Shin3,4, Yohwan Yeo1, Ji Won Chang1, Jung Eun Yoo5, Su-Min Jeong6,7, Se-Kyung Lee8, Jai Min Ryu8, Yong-Moon Park9. 1. Department of Family Medicine & Supportive Care Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-gu, Seoul, 06351, Korea. 2. Department of Statistics and Actuarial Science, Soongsil University, 369 Sangdo-ro, Dongjak-gu, Seoul, 06978, Korea. hkd917@naver.com. 3. Department of Family Medicine & Supportive Care Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-gu, Seoul, 06351, Korea. dwshin.md@gmail.com. 4. Center for Clinical Epidemiology, Samsung Advanced Institute for Health Science & Technology (SAIHST), Sungkyunkwan University, Seoul, Korea. dwshin.md@gmail.com. 5. Department of Family Medicine, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Korea. 6. Department of Family Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Republic of Korea. 7. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 8. Division of Breast Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. 9. Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC, USA.
Abstract
PURPOSE: To examine the association between obesity measured by body mass index (BMI) and waist circumference (WC) according to menopausal status in Korean women. METHODS: We identified 6,467,388 women, using the Korean National Health Insurance System Cohort. Cox-proportional hazard models were used to generate adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for breast cancer risk in relation to BMI and WC. RESULTS: In postmenopausal women, the risk of breast cancer increased with BMI. Compared to women with a BMI of 18.5-23 kg/m two, the risk of invasive breast cancer was lower in patients with BMI < 18.5 (aHR 0.82, 95% CI 0.75-0.89), while it increased linearly in those with BMI 23-25 (1.11, 1.08-1.14), BMI 25-30 (1.28, 1.25-1.32), and BMI ≥ 30 (1.54,1.47-1.62). In contrast, the risk of breast cancer decreased with BMI in premenopausal women. Compared to women with a BMI of 18.5-23, the risk of IBC was similar in those with a BMI < 18.5 (1.02, 0.94-1.11) and BMI 23-25 (1.01, 0.97-1.05), but was significantly lower in those with a BMI 25-30 (0.95, 0.91-0.98) and BMI ≥ 30 (0.90, 0.82-0.98). A relative increase with BMI was less profound for carcinoma in situ in postmenopausal women, and a relative decrease was more profound in premenopausal women. An analysis using WC showed almost identical results. CONCLUSIONS: There was a positive relationship between obesity and breast cancer in postmenopausal women, and an inverse association in premenopausal women.
PURPOSE: To examine the association between obesity measured by body mass index (BMI) and waist circumference (WC) according to menopausal status in Korean women. METHODS: We identified 6,467,388 women, using the Korean National Health Insurance System Cohort. Cox-proportional hazard models were used to generate adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for breast cancer risk in relation to BMI and WC. RESULTS: In postmenopausal women, the risk of breast cancer increased with BMI. Compared to women with a BMI of 18.5-23 kg/m two, the risk of invasive breast cancer was lower in patients with BMI < 18.5 (aHR 0.82, 95% CI 0.75-0.89), while it increased linearly in those with BMI 23-25 (1.11, 1.08-1.14), BMI 25-30 (1.28, 1.25-1.32), and BMI ≥ 30 (1.54,1.47-1.62). In contrast, the risk of breast cancer decreased with BMI in premenopausal women. Compared to women with a BMI of 18.5-23, the risk of IBC was similar in those with a BMI < 18.5 (1.02, 0.94-1.11) and BMI 23-25 (1.01, 0.97-1.05), but was significantly lower in those with a BMI 25-30 (0.95, 0.91-0.98) and BMI ≥ 30 (0.90, 0.82-0.98). A relative increase with BMI was less profound for carcinoma in situ in postmenopausal women, and a relative decrease was more profound in premenopausal women. An analysis using WC showed almost identical results. CONCLUSIONS: There was a positive relationship between obesity and breast cancer in postmenopausal women, and an inverse association in premenopausal women.
Entities:
Keywords:
Body mass index; Breast cancer; Menopause; Obesity; Waist circumference
Authors: Jiyoung Ahn; Arthur Schatzkin; James V Lacey; Demetrius Albanes; Rachel Ballard-Barbash; Kenneth F Adams; Victor Kipnis; Traci Mouw; Albert R Hollenbeck; Michael F Leitzmann Journal: Arch Intern Med Date: 2007-10-22
Authors: Mia M Gaudet; Brian D Carter; Alpa V Patel; Lauren R Teras; Eric J Jacobs; Susan M Gapstur Journal: Cancer Causes Control Date: 2014-04-09 Impact factor: 2.506
Authors: Petra H Lahmann; Kurt Hoffmann; Naomi Allen; Carla H van Gils; Kay-Tee Khaw; Bertrand Tehard; Franco Berrino; Anne Tjønneland; Janne Bigaard; Anja Olsen; Kim Overvad; Françoise Clavel-Chapelon; Gabriele Nagel; Heiner Boeing; Dimitrios Trichopoulos; George Economou; George Bellos; Domenico Palli; Rosario Tumino; Salvatore Panico; Carlotta Sacerdote; Vittorio Krogh; Petra H M Peeters; H Bas Bueno-de-Mesquita; Eiliv Lund; Eva Ardanaz; Pilar Amiano; Guillem Pera; José R Quirós; Carmen Martínez; María J Tormo; Elisabet Wirfält; Göran Berglund; Göran Hallmans; Timothy J Key; Gillian Reeves; Sheila Bingham; Teresa Norat; Carine Biessy; Rudolf Kaaks; Elio Riboli Journal: Int J Cancer Date: 2004-09-20 Impact factor: 7.396
Authors: Annie Tang; Caitlin M Cohan; Keith S Hansen; Genna Beattie; Heather I Greenwood; Rita A Mukhtar Journal: Breast Cancer Res Treat Date: 2021-03-27 Impact factor: 4.872
Authors: Aeran Seol; Wenyu Wang; Se Ik Kim; Youngjin Han; In Sil Park; Juhwan Yoo; HyunA Jo; Kyung-Do Han; Yong Sang Song Journal: Front Oncol Date: 2021-05-27 Impact factor: 6.244