Chongyang She1, Fu Shang2, Min Cui3, Xiufen Yang4, Ningpu Liu5. 1. Department of Ophthalmology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China. 2. Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA. 3. Department of Ophthalmology, Beijing Haidian Hospital, Beijing, China. 4. Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing, China. 5. Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China. nliu001@gmail.com.
Abstract
BACKGROUND: Diabetic retinopathy (DR) is related to oxidative stress and insufficient intake of dietary antioxidants may be associated with the onset and progression of DR. This study aimed to detect the association between main dietary antioxidants intake and the risk for DR. METHODS: This is a cross-sectional study of a Chinese urban population. Four hundred and fifty-five subjects with type 2 diabetes were recruited and divided into diabetic patients without retinopathy (DWR) group and DR group based on their retinal status. CSMO (clinically significant macular oedema) was diagnosed by stereoscopic photography. Demographic and lifestyle characteristics were ascertained by questionnaire. General physical and ophthalmic examinations were completed for all subjects. Dietary antioxidants were assessed by 3-day food records. Subjects who have taken any type of vitamin supplements were excluded from the study. The association of dietary antioxidants with the risk for DR was analysed by logistic regression with adjustment of other factors. The dietary antioxidants levels of the CSMO subjects and non-CSMO subjects were compared using the Wilcoxon rank sum test. RESULTS: One hundred and nineteen subjects in DR group and 336 subjects in DWR group participated in the study. Only ten DR subjects had CSMO. The results showed that higher vitamin E (OR (95% CI):0.97 (0.95, 1.00), P = 0.036) and selenium (OR (95% CI):0.98 (0.96, 1.00), P = 0.017) intake appear to be the protective factors of DR. The dietary antioxidants levels of CSMO and non-CSMO subjects had no statistical differences (P > 0.05). CONCLUSIONS: Dietary antioxidants intake, particularly vitamin E and selenium, were observed to have protective effects on DR.
BACKGROUND: Diabetic retinopathy (DR) is related to oxidative stress and insufficient intake of dietary antioxidants may be associated with the onset and progression of DR. This study aimed to detect the association between main dietary antioxidants intake and the risk for DR. METHODS: This is a cross-sectional study of a Chinese urban population. Four hundred and fifty-five subjects with type 2 diabetes were recruited and divided into diabetic patients without retinopathy (DWR) group and DR group based on their retinal status. CSMO (clinically significant macular oedema) was diagnosed by stereoscopic photography. Demographic and lifestyle characteristics were ascertained by questionnaire. General physical and ophthalmic examinations were completed for all subjects. Dietary antioxidants were assessed by 3-day food records. Subjects who have taken any type of vitamin supplements were excluded from the study. The association of dietary antioxidants with the risk for DR was analysed by logistic regression with adjustment of other factors. The dietary antioxidants levels of the CSMO subjects and non-CSMO subjects were compared using the Wilcoxon rank sum test. RESULTS: One hundred and nineteen subjects in DR group and 336 subjects in DWR group participated in the study. Only ten DR subjects had CSMO. The results showed that higher vitamin E (OR (95% CI):0.97 (0.95, 1.00), P = 0.036) and selenium (OR (95% CI):0.98 (0.96, 1.00), P = 0.017) intake appear to be the protective factors of DR. The dietary antioxidants levels of CSMO and non-CSMO subjects had no statistical differences (P > 0.05). CONCLUSIONS: Dietary antioxidants intake, particularly vitamin E and selenium, were observed to have protective effects on DR.
Authors: Andrés Díaz-López; Nancy Babio; Miguel A Martínez-González; Dolores Corella; Antonio J Amor; Montse Fitó; Ramon Estruch; Fernando Arós; Enrique Gómez-Gracia; Miquel Fiol; José Lapetra; Lluís Serra-Majem; Josep Basora; F Javier Basterra-Gortari; Vicente Zanon-Moreno; Miguel Ángel Muñoz; Jordi Salas-Salvadó Journal: Diabetes Care Date: 2015-09-13 Impact factor: 19.112
Authors: Georgian T Mustata; Mariana Rosca; Klaus M Biemel; Oliver Reihl; Mark A Smith; Ashwini Viswanathan; Christopher Strauch; Yunpeng Du; Jie Tang; Timothy S Kern; Markus O Lederer; Michael Brownlee; Miriam F Weiss; Vincent M Monnier Journal: Diabetes Date: 2005-02 Impact factor: 9.461