Literature DB >> 33008876

Genetic Variants in the Regulatory T cell-Related Pathway and Colorectal Cancer Prognosis.

Sonja Neumeyer1,2, Xinwei Hua3,4, Petra Seibold1, Lina Jansen5, Axel Benner6, Barbara Burwinkel7,8, Niels Halama9,10,11, Sonja I Berndt12, Amanda I Phipps3,13, Lori C Sakoda3,14, Robert E Schoen15, Martha L Slattery16, Andrew T Chan17,18,19, Manish Gala17,19, Amit D Joshi19,20, Shuji Ogino20,21,22, Mingyang Song17,19,20,23, Esther Herpel24,25, Hendrik Bläker26, Matthias Kloor27, Dominique Scherer28, Alexis Ulrich29, Cornelia M Ulrich30,31, Aung K Win32, Jane C Figueiredo33, John L Hopper34, Finlay Macrae34, Roger L Milne32,35, Graham G Giles32,35, Daniel D Buchanan36,37,38, Ulrike Peters3,39, Michael Hoffmeister5, Hermann Brenner5,40,41, Polly A Newcomb2,3, Jenny Chang-Claude42,43.   

Abstract

BACKGROUND: High numbers of lymphocytes in tumor tissue, including T regulatory cells (Treg), have been associated with better colorectal cancer survival. Tregs, a subset of CD4+ T lymphocytes, are mediators of immunosuppression in cancer, and therefore variants in genes related to Treg differentiation and function could be associated with colorectal cancer prognosis.
METHODS: In a prospective German cohort of 3,593 colorectal cancer patients, we assessed the association of 771 single-nucleotide polymorphisms (SNP) in 58 Treg-related genes with overall and colorectal cancer-specific survival using Cox regression models. Effect modification by microsatellite instability (MSI) status was also investigated because tumors with MSI show greater lymphocytic infiltration and have been associated with better prognosis. Replication of significant results was attempted in 2,047 colorectal cancer patients of the International Survival Analysis in Colorectal Cancer Consortium (ISACC).
RESULTS: A significant association of the TGFBR3 SNP rs7524066 with more favorable colorectal cancer-specific survival [hazard ratio (HR) per minor allele: 0.83; 95% confidence interval (CI), 0.74-0.94; P value: 0.0033] was replicated in ISACC (HR: 0.82; 95% CI, 0.68-0.98; P value: 0.03). Suggestive evidence for association was found with two IL7 SNPs, rs16906568 and rs7845577. Thirteen SNPs with differential associations with overall survival according to MSI in the discovery analysis were not confirmed.
CONCLUSIONS: Common genetic variation in the Treg pathway implicating genes such as TGFBR3 and IL7 was shown to be associated with prognosis of colorectal cancer patients. IMPACT: The implicated genes warrant further investigation. ©2020 American Association for Cancer Research.

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Year:  2020        PMID: 33008876      PMCID: PMC7976673          DOI: 10.1158/1055-9965.EPI-20-0714

Source DB:  PubMed          Journal:  Cancer Epidemiol Biomarkers Prev        ISSN: 1055-9965            Impact factor:   4.090


  62 in total

1.  Preferences for potential innovations in non-invasive colorectal cancer screening: A labeled discrete choice experiment for a Dutch screening campaign.

Authors:  Tim M Benning; Benedict G C Dellaert; Carmen D Dirksen; Johan L Severens
Journal:  Acta Oncol       Date:  2014-01-23       Impact factor: 4.089

Review 2.  FOXP3+ regulatory T cells in the human immune system.

Authors:  Shimon Sakaguchi; Makoto Miyara; Cristina M Costantino; David A Hafler
Journal:  Nat Rev Immunol       Date:  2010-06-18       Impact factor: 53.106

3.  Altering the Proteoglycan State of Transforming Growth Factor β Type III Receptor (TβRIII)/Betaglycan Modulates Canonical Wnt/β-Catenin Signaling.

Authors:  Laura M Jenkins; Priyanka Singh; Archana Varadaraj; Nam Y Lee; Shreya Shah; Haley V Flores; Kathleen O'Connell; Karthikeyan Mythreye
Journal:  J Biol Chem       Date:  2016-10-26       Impact factor: 5.157

4.  Interleukin genes and associations with colon and rectal cancer risk and overall survival.

Authors:  Kristina L Bondurant; Abbie Lundgreen; Jennifer S Herrick; Susan Kadlubar; Roger K Wolff; Martha L Slattery
Journal:  Int J Cancer       Date:  2012-06-26       Impact factor: 7.396

Review 5.  Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis.

Authors:  Arnoud J Templeton; Mairéad G McNamara; Boštjan Šeruga; Francisco E Vera-Badillo; Priya Aneja; Alberto Ocaña; Raya Leibowitz-Amit; Guru Sonpavde; Jennifer J Knox; Ben Tran; Ian F Tannock; Eitan Amir
Journal:  J Natl Cancer Inst       Date:  2014-05-29       Impact factor: 13.506

Review 6.  TGF-β receptors: In and beyond TGF-β signaling.

Authors:  Alexandra Vander Ark; Jingchen Cao; Xiaohong Li
Journal:  Cell Signal       Date:  2018-09-07       Impact factor: 4.315

7.  Deriving the consequences of genomic variants with the Ensembl API and SNP Effect Predictor.

Authors:  William McLaren; Bethan Pritchard; Daniel Rios; Yuan Chen; Paul Flicek; Fiona Cunningham
Journal:  Bioinformatics       Date:  2010-06-18       Impact factor: 6.937

Review 8.  Prognostic value of tumor-infiltrating FoxP3+ regulatory T cells in cancers: a systematic review and meta-analysis.

Authors:  Bin Shang; Yao Liu; Shu-juan Jiang; Yi Liu
Journal:  Sci Rep       Date:  2015-10-14       Impact factor: 4.379

9.  Tumor-Associated Macrophages and Regulatory T Cells Infiltration and the Clinical Outcome in Colorectal Cancer.

Authors:  Dariusz Waniczek; Zbigniew Lorenc; Mirosław Śnietura; Mariusz Wesecki; Agnieszka Kopec; Małgorzata Muc-Wierzgoń
Journal:  Arch Immunol Ther Exp (Warsz)       Date:  2017-03-25       Impact factor: 4.291

10.  Prognostic value of CD133+ CD54+ CD44+ circulating tumor cells in colorectal cancer with liver metastasis.

Authors:  Chao Fang; Chuanwen Fan; Cun Wang; Qiaorong Huang; Wentong Meng; Yongyang Yu; Lie Yang; Jiankun Hu; Yuan Li; Xianming Mo; Zongguang Zhou
Journal:  Cancer Med       Date:  2017-11-03       Impact factor: 4.452

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