Xavier Vuillemin1, Constantin Hays2, Céline Plainvert3, Nicolas Dmytruk1, Mathilde Louis1, Gérald Touak4, Benjamin Saint-Pierre5, Lucie Adoux5, Franck Letourneur5, Amandine Frigo1, Claire Poyart2, Asmaa Tazi6. 1. Department of Bacteriology, University Hospitals Paris Centre-Cochin, French National Reference Centre for Streptococci, Assistance Publique-Hôpitaux de Paris, France. 2. Department of Bacteriology, University Hospitals Paris Centre-Cochin, French National Reference Centre for Streptococci, Assistance Publique-Hôpitaux de Paris, France; Cochin Institute, INSERM U1016, UMR CNRS 8104, Team Bacteria and Perinatality, France; University of Paris, Paris, France. 3. Department of Bacteriology, University Hospitals Paris Centre-Cochin, French National Reference Centre for Streptococci, Assistance Publique-Hôpitaux de Paris, France; Cochin Institute, INSERM U1016, UMR CNRS 8104, Team Bacteria and Perinatality, France. 4. Cochin Institute, INSERM U1016, UMR CNRS 8104, Team Bacteria and Perinatality, France. 5. Cochin Institute, INSERM U1016, UMR CNRS 8104, Genomic Platform, France. 6. Department of Bacteriology, University Hospitals Paris Centre-Cochin, French National Reference Centre for Streptococci, Assistance Publique-Hôpitaux de Paris, France; Cochin Institute, INSERM U1016, UMR CNRS 8104, Team Bacteria and Perinatality, France; University of Paris, Paris, France. Electronic address: asmaa.tazi@aphp.fr.
Abstract
OBJECTIVES: Group B Streptococcus (GBS) (Streptococcus agalactiae) is a pathogen of growing importance in adults. The objective of this study was to describe the features of invasive infections by GBS in non-pregnant adults. METHODS: GBS infections were reported to the national reference centre for streptococci. Clinical information was abstracted from questionnaires. Capsular typing, identification of the hypervirulent CC-17 clone, and antibiotic susceptibility testing were performed for all GBS isolates. Multi-locus sequence typing and assignment to clonal complexes (CCs) was performed on a representative sample of 324 isolates. RESULTS: In total, 1960 GBS invasive infections were analysed from 2007 to 2019. The median age at onset was 71 years old (range 18-103). The main manifestation was bacteraemia without focus (54.5%). Meningitis was more frequent in patients under 40 (26/180, 14.4% versus 78/1780, 4.4%, p < 0.0001). Capsular types Ia, Ib, II, III and V accounted for 91.0% of the cases (1786/1960). CC-1, -10, -17, -19 and -23 accounted for 96.3% (312/324) of the cases. Capsular type III and CC-17 were overrepresented in meningitis (38/104, 36.5%, p < 0.001 and 22/104, 21.2%, p 0.01, respectively). All isolates were susceptible to β-lactam antibiotics. Resistance to erythromycin (32.7%) and clindamycin (26.3%) remained stable, whereas decreased susceptibility to fluoroquinolones increased, reaching 2.7% in 2019 (p for trend 0.002). CONCLUSIONS: This work highlights the susceptibility of the elderly to GBS infections and differences in the clinical manifestations according to the patients' age and GBS type. In agreement with worldwide reports on emerging multidrug-resistant GBS, it reinforces the need for a continued surveillance of GBS epidemiology.
OBJECTIVES:Group B Streptococcus (GBS) (Streptococcus agalactiae) is a pathogen of growing importance in adults. The objective of this study was to describe the features of invasive infections by GBS in non-pregnant adults. METHODS:GBS infections were reported to the national reference centre for streptococci. Clinical information was abstracted from questionnaires. Capsular typing, identification of the hypervirulent CC-17 clone, and antibiotic susceptibility testing were performed for all GBS isolates. Multi-locus sequence typing and assignment to clonal complexes (CCs) was performed on a representative sample of 324 isolates. RESULTS: In total, 1960 GBS invasive infections were analysed from 2007 to 2019. The median age at onset was 71 years old (range 18-103). The main manifestation was bacteraemia without focus (54.5%). Meningitis was more frequent in patients under 40 (26/180, 14.4% versus 78/1780, 4.4%, p < 0.0001). Capsular types Ia, Ib, II, III and V accounted for 91.0% of the cases (1786/1960). CC-1, -10, -17, -19 and -23 accounted for 96.3% (312/324) of the cases. Capsular type III and CC-17 were overrepresented in meningitis (38/104, 36.5%, p < 0.001 and 22/104, 21.2%, p 0.01, respectively). All isolates were susceptible to β-lactam antibiotics. Resistance to erythromycin (32.7%) and clindamycin (26.3%) remained stable, whereas decreased susceptibility to fluoroquinolones increased, reaching 2.7% in 2019 (p for trend 0.002). CONCLUSIONS: This work highlights the susceptibility of the elderly to GBS infections and differences in the clinical manifestations according to the patients' age and GBS type. In agreement with worldwide reports on emerging multidrug-resistant GBS, it reinforces the need for a continued surveillance of GBS epidemiology.
Authors: Vu Van Du; Pham Thai Dung; Nguyen Linh Toan; Can Van Mao; Nguyen Thanh Bac; Hoang Van Tong; Ho Anh Son; Nghiem Duc Thuan; Nguyen Thanh Viet Journal: Sci Rep Date: 2021-10-21 Impact factor: 4.379
Authors: Anu Chacko; Ali Delbaz; Indra N Choudhury; Tanja Eindorf; Megha Shah; Christopher Godfrey; Matthew J Sullivan; James A St John; Glen C Ulett; Jenny A K Ekberg Journal: Front Cell Infect Microbiol Date: 2022-02-24 Impact factor: 5.293