Vivek M Tarsariya1, Dhaval N Mehta2, Nilesh Raval3, Hiren H Patadiya4, Kanan Vachhrajani5, Albert Ashem6. 1. Shantabaa Medical College & General Hospital, Amreli, Gujarat, India. 2. Dept. of Oral Medicine & Radiology, Narsinhbhai Patel Dental College & Hospital, Visnagar, Gujarat, India. 3. Dept. of Oral Medicine & Radiology, Karnavati School of Dentistry, Uvarsad, Gandhinagar, Gujarat, India. 4. Boston University, Henry M Goldman School of Dental Medicine, Boston, USA. 5. University of Toronto, Canada. 6. Dental College, RIMS, Imphal, Manipur, India.
Abstract
BACKGROUND: Only few studies have been done to evaluate level of serum immunoglobulins (IgG,IgM,IgA) in patients with Potentially Malignant Disorders (PMD) like Leukoplakia, Oral Submucous Fibrosis (OSMF) and Oral Lichen Planus (OLP) as tumour markers. AIMS AND OBJECTIVES: To estimate the serum immunoglobulins level (IgG, IgM, IgA) in leukoplakia, OSMF and oral lichen planus (OLP) patients and its comparison with levels among control groups and Weather these values can be used to predict severity of disease or not. MATERIALS AND METHODS: 30 patients with different potentially malignant disorders like leukoplakia, OSMF and oral lichen planus and 30 healthy controls were selected at random and subjected for analysis of serum IgG, IgA, IgM. Statistical methods employed were mean, standard deviation and ANOVA test. RESULTS: We observed significant elevated levels of all the immunoglobulins in leukoplakia, OSMF and oral lichen planus when compared with the control group and levels were increasing with clinical stages of OSMF (p < 0.05). CONCLUSIONS: All these immunoglobulins are indicative of tumour burden or transformation of malignancy in higher stage and might be employed as prognostic indicators in these disorders.
BACKGROUND: Only few studies have been done to evaluate level of serum immunoglobulins (IgG,IgM,IgA) in patients with Potentially Malignant Disorders (PMD) like Leukoplakia, Oral Submucous Fibrosis (OSMF) and Oral Lichen Planus (OLP) as tumour markers. AIMS AND OBJECTIVES: To estimate the serum immunoglobulins level (IgG, IgM, IgA) in leukoplakia, OSMF and oral lichen planus (OLP) patients and its comparison with levels among control groups and Weather these values can be used to predict severity of disease or not. MATERIALS AND METHODS: 30 patients with different potentially malignant disorders like leukoplakia, OSMF and oral lichen planus and 30 healthy controls were selected at random and subjected for analysis of serum IgG, IgA, IgM. Statistical methods employed were mean, standard deviation and ANOVA test. RESULTS: We observed significant elevated levels of all the immunoglobulins in leukoplakia, OSMF and oral lichen planus when compared with the control group and levels were increasing with clinical stages of OSMF (p < 0.05). CONCLUSIONS: All these immunoglobulins are indicative of tumour burden or transformation of malignancy in higher stage and might be employed as prognostic indicators in these disorders.
Authors: Anant Narayan Bhatt; Rohit Mathur; Abdullah Farooque; Amit Verma; B S Dwarakanath Journal: Indian J Med Res Date: 2010-08 Impact factor: 2.375
Authors: C Neuchrist; J Kornfehl; M Grasl; H Lassmann; D Kraft; K Ehrenberger; O Scheiner Journal: Int Arch Allergy Immunol Date: 1994-05 Impact factor: 2.749