| Literature DB >> 33004259 |
Daniel Enosi Tuipulotu1, Anukriti Mathur1, Chinh Ngo1, Si Ming Man2.
Abstract
The toxin-producing bacterium Bacillus cereus is an important and neglected human pathogen and a common cause of food poisoning. Several toxins have been implicated in disease, including the pore-forming toxins hemolysin BL (HBL) and nonhemolytic enterotoxin (NHE). Recent work revealed that HBL binds to the mammalian surface receptors LITAF and CDIP1 and that both HBL and NHE induce potassium efflux and activate the NLRP3 inflammasome, leading to pyroptosis. These mammalian receptors, in part, contribute to inflammation and pathology. Other putative virulence factors of B. cereus include cytotoxin K, cereulide, metalloproteases, sphingomyelinase, and phospholipases. In this review, we highlight the latest progress in our understanding of B. cereus biology, epidemiology, and pathogenesis, and discuss potential new directions for research in this field.Entities:
Keywords: IL-1; IL-18; S-layer; Toll-like receptors; anthrax; bacteremia; caspase-1; cytokines; emesis; endophthalmitis; endospores; flagella; gasdermin; gasgangrene; gastroenteritis; gut microbiome; gut microbiota; mesophilic; psychrotrophic; respiratory tract infections
Year: 2020 PMID： 33004259 DOI： 10.1016/j.tim.2020.09.003
Source DB: PubMed Journal: Trends Microbiol ISSN： 0966-842X Impact factor: 17.079