Hetashi Bawa1, Lydia Poole2, Debbie Cooke3, Laura Panagi4, Andrew Steptoe5, Ruth A Hackett6. 1. Department of Behavioural Science and Health, University College London, London, UK. Electronic address: Hetashi.bawa.18@ucl.ac.uk. 2. Department of Behavioural Science and Health, University College London, London, UK. Electronic address: lydia.poole@ucl.ac.uk. 3. School of Health Sciences, University of Surrey, Guildford, Surrey, UK. Electronic address: d.cooke@surrey.ac.uk. 4. Department of Behavioural Science and Health, University College London, London, UK. Electronic address: laura.panagi.16@ucl.ac.uk. 5. Department of Behavioural Science and Health, University College London, London, UK. Electronic address: a.steptoe@ucl.ac.uk. 6. Department of Behavioural Science and Health, University College London, London, UK; Health Psychology Section, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. Electronic address: ruth.hackett@kcl.ac.uk.
Abstract
AIMS: Diabetes-related distress is common in Type 2 Diabetes and is linked with poor diabetes control. However, mechanisms underlying this association are unclear. One pathway that could be involved is neuroendocrine dysfunction, as Type 2 Diabetes is associated with altered diurnal cortisol output. This study investigated the link between diabetes-related distress and diurnal cortisol output. METHODS: 134 people with Type 2 Diabetes provided 5 cortisol samples over the course of a day. Multivariate linear regression models were used to assess whether overall and sub-domains of diabetes-related distress measured by the Diabetes Distress Scale, predicted cortisol parameters (waking cortisol, cortisol awakening response, cortisol slope and evening cortisol). RESULTS: Physician-related distress was associated with greater waking (B = 2.747, p = .015) and evening cortisol (B = 1.375, p = .014), and a blunted cortisol awakening response (B = -3.472, p = .038) adjusting for age, sex, income, body mass index, smoking and time of awakening. No associations were detected for overall distress, emotional, interpersonal or regimen distress. CONCLUSION: Physician-related distress was associated with alterations in daily cortisol output. Longitudinal research is required to understand how physician-related distress is associated with diurnal cortisol patterning over time.
AIMS: Diabetes-related distress is common in Type 2 Diabetes and is linked with poor diabetes control. However, mechanisms underlying this association are unclear. One pathway that could be involved is neuroendocrine dysfunction, as Type 2 Diabetes is associated with altered diurnal cortisol output. This study investigated the link between diabetes-related distress and diurnal cortisol output. METHODS: 134 people with Type 2 Diabetes provided 5 cortisol samples over the course of a day. Multivariate linear regression models were used to assess whether overall and sub-domains of diabetes-related distress measured by the Diabetes Distress Scale, predicted cortisol parameters (waking cortisol, cortisol awakening response, cortisol slope and evening cortisol). RESULTS: Physician-related distress was associated with greater waking (B = 2.747, p = .015) and evening cortisol (B = 1.375, p = .014), and a blunted cortisol awakening response (B = -3.472, p = .038) adjusting for age, sex, income, body mass index, smoking and time of awakening. No associations were detected for overall distress, emotional, interpersonal or regimen distress. CONCLUSION: Physician-related distress was associated with alterations in daily cortisol output. Longitudinal research is required to understand how physician-related distress is associated with diurnal cortisol patterning over time.