Literature DB >> 3300117

Septic shock in the rat: activation of plasma proteolytic systems and effects of a kallikrein inhibitor/bradykinin antagonist (S-2441).

H Högström, G Claeson, C Larsson-Backström, D Lundberg, E Wenngren, U Haglund.   

Abstract

Septic shock was induced in rats by intraperitoneal injection of live Escherichia coli. Plasma prekallikrein, antithrombin III and plasminogen levels were studied with chromogenic peptide substrate assays. Decrease of all the studied plasma components occurred in all rats, but not until late in shock. S-2441, a kallikrein inhibitor/kinin antagonist, slightly delayed the fall in plasma prekallikrein, but no other effects were found. Rat survival was neither enhanced nor prolonged.

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Year:  1987        PMID： 3300117

Source DB:  PubMed          Journal:  Acta Chir Scand        ISSN： 0001-5482


  4 in total

1.  [Early phase of healing of anastomoses with special reference to peritonitis and ischemia].

Authors:  D Wilker; J Sklarek; H Waldner; J R Izbicki; M Siebeck
Journal:  Langenbecks Arch Chir       Date:  1988

2.  Local L-NG-monomethyl-arginine attenuates the vasodilator action of bradykinin in the human forearm.

Authors:  K P O'Kane; D J Webb; J G Collier; P J Vallance
Journal:  Br J Clin Pharmacol       Date:  1994-10       Impact factor: 4.335

3.  Evidence for the involvement of a plasma kallikrein-kinin system in the immediate hypotension produced by endotoxin in anaesthetized rats.

Authors:  M Katori; M Majima; R Odoi-Adome; N Sunahara; Y Uchida
Journal:  Br J Pharmacol       Date:  1989-12       Impact factor: 8.739

4.  Attenuation of arterial blood pressure fall in endotoxin shock in the rat using the competitive bradykinin antagonist Lys-Lys-[Hyp2, Thi5,8, DPhe7]-Bk (B4148).

Authors:  J Weipert; H Hoffmann; M Siebeck; E T Whalley
Journal:  Br J Pharmacol       Date:  1988-06       Impact factor: 8.739
  4 in total

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