Literature DB >> 32999536

Predictors of hyponatremia following elective primary unilateral knee arthroplasty at a tertiary centre: A retrospective observational cohort and predictive model.

Navneet Singh1, Joyce Y Tai2, Julian Dimech2, Nicholas J Gormack3, Andrew J D Cameron2, Nicholas J Lightfoot2.   

Abstract

INTRODUCTION: Hyponatremia is a common electrolyte disorder. This can be associated with nausea, disorientation and in more serious cases a decreased level of consciousness or neurological deficits. These symptoms may lead to increases in the cost of hospital care and significant morbidity. The purpose of this retrospective, observational cohort study is to investigate the impact of hyponatremia on patient and systems specific outcome measures in those undergoing elective, unilateral total knee arthroplasty (TKA) at two hospitals in Auckland, New Zealand over a twelve-month period.
MATERIALS AND METHODS: Patients were stratified into two groups based on the presence or absence of post-operative hyponatremia (defined as a blood sodium of <135 mmol/L with a concurrent decrease of ≥5 mmol/L between the pre- and post-operative recordings). Outcomes collected included Quality of Recovery - 15 (QOR) scores, time to assisted mobilisation, discharge ICD-10 complication codes and hospital length of stay.
RESULTS: During the study period 236 patients underwent surgery. Eighty-six (36.4%) patients met criteria for post-operative hyponatremia. This finding was associated with prolongation of the hospital length of stay (4.17 (3.26-5.18) versus 4.28 (3.31-5.45) days, p = 0.031) and a reduction in the QOR score on the second post-operative day (113.0 (99.5-126.5) versus 105.0 (94.0-118.0), p = 0.039). There was no difference in the time to assisted mobilisation.
CONCLUSIONS: Hyponatremia is a common finding following TKA. This abnormality is associated with small changes in patient specific outcome measures. These implications of these findings may become more significant in settings where same day or rapid discharge from hospital is targeted.
© 2020 Professor P K Surendran Memorial Education Foundation. Published by Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Complications; Electrolyte disorders; Hyponatremia; Patient centred outcomes; Perioperative medicine; Total knee replacement

Year:  2020        PMID: 32999536      PMCID: PMC7501472          DOI: 10.1016/j.jor.2020.09.004

Source DB:  PubMed          Journal:  J Orthop        ISSN: 0972-978X


  26 in total

1.  Hyponatraemia after orthopaedic surgery.

Authors:  N Lane; K Allen
Journal:  BMJ       Date:  1999-05-22

2.  Electrolyte imbalance after total joint arthroplasty: risk factors and impact on length of hospital stay.

Authors:  Ravikumar Mukartihal; Harish G Puranik; Sharan Shivaraj Patil; Soundar Rajan Dhanasekaran; Venugopal K Menon
Journal:  Eur J Orthop Surg Traumatol       Date:  2019-06-19

Review 3.  Hyponatraemia - presentations and management.

Authors:  Rosemary Dineen; Christopher J Thompson; Mark Sherlock
Journal:  Clin Med (Lond)       Date:  2017-06       Impact factor: 2.659

Review 4.  The vasopressin system: physiology and clinical strategies.

Authors:  Tanja A Treschan; Jürgen Peters
Journal:  Anesthesiology       Date:  2006-09       Impact factor: 7.892

5.  Development of severe hyponatraemia in hospitalized patients: treatment-related risk factors and inadequate management.

Authors:  Ewout J Hoorn; Jan Lindemans; Robert Zietse
Journal:  Nephrol Dial Transplant       Date:  2005-09-02       Impact factor: 5.992

Review 6.  Perioperative Pain Management in Hip and Knee Arthroplasty.

Authors:  Christian J Gaffney; Christopher E Pelt; Jeremy M Gililland; Christopher L Peters
Journal:  Orthop Clin North Am       Date:  2017-06-29       Impact factor: 2.472

Review 7.  Diagnosis and treatment of hyponatraemia in neurosurgical patients.

Authors:  Martín Cuesta; Mark J Hannon; Christopher J Thompson
Journal:  Endocrinol Nutr       Date:  2016-03-08

Review 8.  Hyponatremia in Cirrhosis: Implications for Liver Transplantation.

Authors:  Michael Leise; Andrés Cárdenas
Journal:  Liver Transpl       Date:  2018-11       Impact factor: 5.799

Review 9.  Incidence and prevalence of hyponatremia.

Authors:  Ashish Upadhyay; Bertrand L Jaber; Nicolaos E Madias
Journal:  Am J Med       Date:  2006-07       Impact factor: 4.965

10.  Why still in hospital after fast-track hip and knee arthroplasty?

Authors:  Henrik Husted; Troels H Lunn; Anders Troelsen; Lissi Gaarn-Larsen; Billy B Kristensen; Henrik Kehlet
Journal:  Acta Orthop       Date:  2011-11-09       Impact factor: 3.717

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