Katherine Carome1,2, Amanda Rahman3,4, Boriana Parvez5. 1. Department of Pediatrics, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 60611, USA. 2. Division of Newborn Medicine, New York Medical College, Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, NY, 11595, USA. 3. Westchester Medical Center, Division of Newborn Medicine, Maria Fareri Children's Hospital, Valhalla, NY, 11595, USA. arahman18@northwell.edu. 4. Department of Pediatrics, Neonatal-Perinatal Medicine, Staten Island University Hospital, 475 Seaview Avenue, Staten Island, NY, 10305, USA. arahman18@northwell.edu. 5. Westchester Medical Center, Division of Newborn Medicine, Maria Fareri Children's Hospital, Valhalla, NY, 11595, USA.
Abstract
OBJECTIVE: Compare the incidence of severe (grade III/IV) intraventricular hemorrhage (IVH) and/or periventricular leukomalacia (PVL) between two groups of ELBW infants based on diet until 34 weeks corrected gestational age (CGA): (1) Exclusive human milk (EHM)-mother's own and/or pasteurized donor human milk, human milk-derived fortifier, and oral care with colostrum/human milk vs. (2) non-EHM-bovine formula or mother's own milk with bovine-derived fortifier. STUDY DESIGN: Retrospective observational study of two groups of ELBW infants based on diet until 34 weeks CGA. RESULT: There were n = 306 infants, 127 EHM and 179 non-EHM. Demographics and morbidities were similar except higher antenatal steroids and NEC in EHM group. The rate of severe IVH/PVL was lower in EHM compared to non-EHM group (7 vs. 18%, p < 0.006). CONCLUSION: EHM diet had an independent neuroprotective effect and was associated with decreased incidence of severe IVH/PVL, supporting the need of EHM in ELBW infants.
OBJECTIVE: Compare the incidence of severe (grade III/IV) intraventricular hemorrhage (IVH) and/or periventricular leukomalacia (PVL) between two groups of ELBW infants based on diet until 34 weeks corrected gestational age (CGA): (1) Exclusive human milk (EHM)-mother's own and/or pasteurized donor human milk, human milk-derived fortifier, and oral care with colostrum/human milk vs. (2) non-EHM-bovine formula or mother's own milk with bovine-derived fortifier. STUDY DESIGN: Retrospective observational study of two groups of ELBW infants based on diet until 34 weeks CGA. RESULT: There were n = 306 infants, 127 EHM and 179 non-EHM. Demographics and morbidities were similar except higher antenatal steroids and NEC in EHM group. The rate of severe IVH/PVL was lower in EHM compared to non-EHM group (7 vs. 18%, p < 0.006). CONCLUSION: EHM diet had an independent neuroprotective effect and was associated with decreased incidence of severe IVH/PVL, supporting the need of EHM in ELBW infants.
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