Rafael Correia Cavalcante1, Guilherme Tomasetti2. 1. Oral and Maxillofacial Surgeon at Bupa-Care Plus Assistencial Medicine, São Paulo, Brazil. Electronic address: rafaelcorreia14@gmail.com. 2. General Surgeon at Private Hospital, Curitiba, Brazil.
Abstract
PURPOSE: Medication-related osteonecrosis of the jaw (MRONJ) is a previously described debilitating condition in which patients experience progressive bone destruction in the maxilla and/or mandible after exposure to certain drugs. Clinical management of MRONJ remains controversial, with no established guidelines. The aim of our study was to conduct a literature review on the effectiveness of pentoxifylline (PTX) and tocopherol (PENTO protocol) on MRONJ. STUDY DESIGN: A literature review was conducted, using two different scientific databases, to evaluate the effects of PTX and tocopherol on MRONJ. DISCUSSION: PENTO protocol prescription to treat MRONJ was reported to be well tolerated, with minimal side-effects, and non-expensive when compared with other non-surgical treatment modalities. It was shown to relieve painful symptoms in all patients, and significant new bone formation was observed at final follow-up. CONCLUSION: Observational and case-series studies have demonstrated that pentoxifylline and tocopherol are potentially useful in the non-surgical management of MRONJ.
PURPOSE: Medication-related osteonecrosis of the jaw (MRONJ) is a previously described debilitating condition in which patients experience progressive bone destruction in the maxilla and/or mandible after exposure to certain drugs. Clinical management of MRONJ remains controversial, with no established guidelines. The aim of our study was to conduct a literature review on the effectiveness of pentoxifylline (PTX) and tocopherol (PENTO protocol) on MRONJ. STUDY DESIGN: A literature review was conducted, using two different scientific databases, to evaluate the effects of PTX and tocopherol on MRONJ. DISCUSSION: PENTO protocol prescription to treat MRONJ was reported to be well tolerated, with minimal side-effects, and non-expensive when compared with other non-surgical treatment modalities. It was shown to relieve painful symptoms in all patients, and significant new bone formation was observed at final follow-up. CONCLUSION: Observational and case-series studies have demonstrated that pentoxifylline and tocopherol are potentially useful in the non-surgical management of MRONJ.
Authors: Anna Winter; Stefan M Schulz; Marc Schmitter; Roman C Brands; Anton Straub; Alexander Kübler; Anna Borgmann; Stefan Hartmann Journal: Int J Environ Res Public Health Date: 2022-09-16 Impact factor: 4.614