Literature DB >> 32998156

The major genetic risk factor for severe COVID-19 is inherited from Neanderthals.

Hugo Zeberg1,2, Svante Pääbo3,4.   

Abstract

A recent genetic association study1 identified a gene cluster on chromosome 3 as a risk locus for respiratory failure after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A separate study (COVID-19 Host Genetics Initiative)2 comprising 3,199 hospitalized patients with coronavirus disease 2019 (COVID-19) and control individuals showed that this cluster is the major genetic risk factor for severe symptoms after SARS-CoV-2 infection and hospitalization. Here we show that the risk is conferred by a genomic segment of around 50 kilobases in size that is inherited from Neanderthals and is carried by around 50% of people in south Asia and around 16% of people in Europe.

Entities:  

Mesh：

Year:  2020        PMID： 32998156     DOI： 10.1038/s41586-020-2818-3

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  144 in total

1.  SI epidemic model applied to COVID-19 data in mainland China.

Authors:  J Demongeot; Q Griette; P Magal
Journal:  R Soc Open Sci       Date:  2020-12-02       Impact factor: 2.963

2.  Genetic variability in COVID-19-related genes in the Brazilian population.

Authors:  Rodrigo Secolin; Tânia K de Araujo; Marina C Gonsales; Cristiane S Rocha; Michel Naslavsky; Luiz De Marco; Maria A C Bicalho; Vinicius L Vazquez; Mayana Zatz; Wilson A Silva; Iscia Lopes-Cendes
Journal:  Hum Genome Var       Date:  2021-04-02

Review 3.  Systematic Review on Local Ancestor Inference From a Mathematical and Algorithmic Perspective.

Authors:  Jie Wu; Yangxiu Liu; Yiqiang Zhao
Journal:  Front Genet       Date:  2021-05-24       Impact factor: 4.599

Review 4.  A review of COVID-19 biomarkers and drug targets: resources and tools.

Authors:  Francesca P Caruso; Giovanni Scala; Luigi Cerulo; Michele Ceccarelli
Journal:  Brief Bioinform       Date:  2021-03-22       Impact factor: 11.622

Review 5.  Therapeutic Potential of Exploiting Autophagy Cascade Against Coronavirus Infection.

Authors:  Subhajit Maity; Abhik Saha
Journal:  Front Microbiol       Date:  2021-05-14       Impact factor: 5.640

6.  Integrative genomics analysis reveals a 21q22.11 locus contributing risk to COVID-19.

Authors:  Yunlong Ma; Yukuan Huang; Sen Zhao; Yinghao Yao; Yaru Zhang; Jia Qu; Nan Wu; Jianzhong Su
Journal:  Hum Mol Genet       Date:  2021-06-17       Impact factor: 6.150

7.  Global variation of COVID-19 mortality rates in the initial phase.

Authors:  Saman Hasan Siddiqui; Azza Sarfraz; Arjumand Rizvi; Fariha Shaheen; Mohammad Tahir Yousafzai; Syed Asad Ali
Journal:  Osong Public Health Res Perspect       Date:  2021-04-29

Review 8.  Does Genetic Predisposition Contribute to the Exacerbation of COVID-19 Symptoms in Individuals with Comorbidities and Explain the Huge Mortality Disparity between the East and the West?

Authors:  Naoki Yamamoto; Rain Yamamoto; Yasuo Ariumi; Masashi Mizokami; Kunitada Shimotohno; Hiroshi Yoshikura
Journal:  Int J Mol Sci       Date:  2021-05-08       Impact factor: 5.923

9.  MHC Haplotyping of SARS-CoV-2 Patients: HLA Subtypes Are Not Associated with the Presence and Severity of COVID-19 in the Israeli Population.

Authors:  Shay Ben Shachar; Noam Barda; Sigal Manor; Sapir Israeli; Noa Dagan; Shai Carmi; Ran Balicer; Bracha Zisser; Yoram Louzoun
Journal:  J Clin Immunol       Date:  2021-05-29       Impact factor: 8.317

10.  The major genetic risk factor for severe COVID-19 does not show any association among South Asian populations.

Authors:  Prajjval Pratap Singh; Anshika Srivastava; Gazi Nurun Nahar Sultana; Nargis Khanam; Abhishek Pathak; Prashanth Suravajhala; Royana Singh; Pankaj Shrivastava; George van Driem; Kumarasamy Thangaraj; Gyaneshwer Chaubey
Journal:  Sci Rep       Date:  2021-06-11       Impact factor: 4.379
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