Sheila de Oliveira Garcia Mateos1,2, Liliana Preiss3, Thelma T Gonçalez4, Claudia Di Lorenzo Oliveira5, Eduard Grebe4,6, Clara Di Germanio4, Mars Stone4, Luiz Amorim Filho2, Anna Bárbara Carneiro Proietti7, Andre Rolim Belisario7, Cesar de Almeida-Neto8,9, Alfredo Mendrone-Junior8, Paula Loureiro10,11, Michael P Busch4,6, Brian Custer4,6, Ester Cerdeira Sabino1,12. 1. Departamento de Moléstias Infecciosas e Parasitárias da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. 2. Department of Hemotherapy, Hemorio, Rio de Janeiro, Brazil. 3. Division of Biostatistics and Epidemiology, RTI International, Rockville, MD, USA. 4. Vitalant Research Institute, San Francisco, CA, USA. 5. Federal University of Sao Joao del-Rei, Minas Gerais, Brazil. 6. University of California San Francisco, San Francisco, CA, USA. 7. Department GDTC (Technical-Scientific Development Management), Hemominas, Minas Gerais, Brazil. 8. Fundação Pró-Sangue Hemocentro de São Paulo, São Paulo, Brazil. 9. Disciplina de Ciências Médicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. 10. Pernambuco University, Recife, Brazil. 11. Fundação Hemope/Hemocentro de Pernambuco, Recife, Brazil. 12. Instituto de Medicina Tropical da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Abstract
BACKGROUND AND OBJECTIVES: Incidence in first-time and repeat blood donors is an important measure of transfusion-transmitted HIV infection (TT-HIV) risk. This study assessed HIV incidence over time at four large blood centres in Brazil. MATERIALS AND METHODS: Donations were screened and confirmed using serological assays for HIV from 2007 to 2016, and additionally screened by nucleic acid testing from 2011 forward. Limiting antigen (LAg) avidity testing was conducted on HIV seroreactive samples from first-time donors to classify whether an infection was recently acquired. We calculated incidence in first-time donors using the mean duration of recent infection and in repeat donors using classical methods. Time and demographic trends were assessed using Poisson regression. RESULTS: Over the 10-year period, HIV incidence in first-time donors was highest in Recife (45·1/100 000 person-years (105 py)) followed by São Paulo (32·2/105 py) and then Belo Horizonte (23·3/105 py), and in repeat donors was highest in Recife (33·2/105 py), Belo Horizonte (27·5/105 py) and São Paulo (17·0/105 py). Results from Rio de Janeiro were available from 2013 to 2016 with incidence in first-time donors of 35·9/105 py and repeat donors from 2011 to 2016 of 29·2/105 py. Incidence varied by other donor demographics. When incidence was considered in 2-year intervals, no significant trend was evident. Overall residual risk of TT-HIV was 5·46 and 7·41 per million units of pRBC and FFP transfused, respectively. CONCLUSION: HIV incidence in both first-time and repeat donors varied by region in Brazil. Clear secular trends were not evident.
BACKGROUND AND OBJECTIVES: Incidence in first-time and repeat blood donors is an important measure of transfusion-transmitted HIV infection (TT-HIV) risk. This study assessed HIV incidence over time at four large blood centres in Brazil. MATERIALS AND METHODS: Donations were screened and confirmed using serological assays for HIV from 2007 to 2016, and additionally screened by nucleic acid testing from 2011 forward. Limiting antigen (LAg) avidity testing was conducted on HIV seroreactive samples from first-time donors to classify whether an infection was recently acquired. We calculated incidence in first-time donors using the mean duration of recent infection and in repeat donors using classical methods. Time and demographic trends were assessed using Poisson regression. RESULTS: Over the 10-year period, HIV incidence in first-time donors was highest in Recife (45·1/100 000 person-years (105 py)) followed by São Paulo (32·2/105 py) and then Belo Horizonte (23·3/105 py), and in repeat donors was highest in Recife (33·2/105 py), Belo Horizonte (27·5/105 py) and São Paulo (17·0/105 py). Results from Rio de Janeiro were available from 2013 to 2016 with incidence in first-time donors of 35·9/105 py and repeat donors from 2011 to 2016 of 29·2/105 py. Incidence varied by other donor demographics. When incidence was considered in 2-year intervals, no significant trend was evident. Overall residual risk of TT-HIV was 5·46 and 7·41 per million units of pRBC and FFP transfused, respectively. CONCLUSION: HIV incidence in both first-time and repeat donors varied by region in Brazil. Clear secular trends were not evident.
Authors: C D L Oliveira; T Goncalez; D Wright; P C Rocha; C Miranda; L Capuani; A B Carneiro-Proietti; F A Proietti; C de Almeida-Neto; N M Larsen; D Sampaio; B Custer Journal: Vox Sang Date: 2012-08-15 Impact factor: 2.144
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Authors: Elizabeth C Moreno; Roberta Bruhn; Ester C Sabino; Eduarda Bolina-Santos; Carolina Miranda; Anna Barbara Carneiro-Proietti; Maria Esther Lopes; Cesar de Almeida-Neto; Paula Loureiro; Ligia Capuani; Pedro L Takecian; Brian Custer; Thelma T Gonçalez Journal: Hematol Transfus Cell Ther Date: 2019-02-18
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