| Literature DB >> 32996457 |
Rahmah Noordin1, Muhammad Hafiznur Yunus1, Syazwan Saidin1,2, Zeehaida Mohamed3, Isabel Fuentes Corripio4, José Miguel Rubio4, Majid Golkar5, Shamilah Hisam6, Rogan Lee7, Rohela Mahmud8.
Abstract
Independent evaluations of XEh Rapid®, an IgG4-based rapid dipstick test, were performed to assess its diagnostic performance to detect amebic liver abscess (ALA) using 405 samples at seven laboratories in four countries. The test showed high diagnostic specificity (97-100%) when tested with samples from healthy individuals (n = 100) and patients with other diseases (n = 151). The diagnostic sensitivity was tested with a total of 154 samples, and the results were variable. It was high in three laboratories (89-94%), and moderate (72%) and low (38%) in two other laboratories. Challenges and issues faced in the evaluation process are discussed. Nevertheless, XEh Rapid is promising to be developed into a point-of-care test in particular for resource-limited settings, and thus merits further confirmation of its diagnostic sensitivity.Entities:
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Year: 2020 PMID： 32996457 PMCID： PMC7695048 DOI： 10.4269/ajtmh.20-0348
Source DB: PubMed Journal: Am J Trop Med Hyg ISSN： 0002-9637 Impact factor: 3.707