Krupal B Patel1, Daniel Martin2, Songzhu Zhao3, Bhavna Kumar1, Ricardo Carrau1, Enver Ozer1, Amit Agrawal1, Stephen Kang1, James W Rocco1, David Schuller1, Theodoros Teknos4, Guy Brock3, Matthew Old1. 1. Department of Otolaryngology-Head and Neck Surgery, The James Cancer Hospital and Solove Research Institute, Wexner Medical Center at The Ohio State University, Columbus, Ohio, USA. 2. School of Medicine & Dentistry, University of Rochester, Rochester, New York, USA. 3. Department of Biomedical Informatics, Center for Biostatistics, The Ohio State University College of Medicine, Columbus, Ohio, USA. 4. Department of Otolaryngology-Head and Neck Surgery, Case Western University, Cleveland, Ohio, USA.
Abstract
OBJECTIVE: To identify predictors of overall survival (OS) and to stratify patients according to significant prognostic variables. METHODS: A retrospective study of 274 consecutive patients with primary Oral Cavity Squamous Cell Carcinoma. Kaplan-Meier, Cox proportional hazard models, and recursive partitioning analysis (RPA) were used for analysis of OS. These results were further validated using National Cancer Database cohort of 21 895 patients. RESULTS: Median OS was 3.65 years. T-classification and N-classification, alcoholic beverages/week, age, and adjuvant treatment were significant predictors of OS. RPA identified high-risk subpopulations: N0-1 patients with CCI ≥ 4.5 and N2-3 patients ordered by those not receiving adjuvant treatment, those with T3-4 disease despite adjuvant therapy, and those having T1-2 disease with adjuvant therapy. CONCLUSIONS: This study utilized significant prognostic indicators and RPA to highlight the importance of age, N-classification, T-classification, comorbidity, and adjuvant therapy in conjunction with American Joint Committee on Cancer staging to improve preoperative counseling.
OBJECTIVE: To identify predictors of overall survival (OS) and to stratify patients according to significant prognostic variables. METHODS: A retrospective study of 274 consecutive patients with primary Oral Cavity Squamous Cell Carcinoma. Kaplan-Meier, Cox proportional hazard models, and recursive partitioning analysis (RPA) were used for analysis of OS. These results were further validated using National Cancer Database cohort of 21 895 patients. RESULTS: Median OS was 3.65 years. T-classification and N-classification, alcoholic beverages/week, age, and adjuvant treatment were significant predictors of OS. RPA identified high-risk subpopulations: N0-1 patients with CCI ≥ 4.5 and N2-3 patients ordered by those not receiving adjuvant treatment, those with T3-4 disease despite adjuvant therapy, and those having T1-2 disease with adjuvant therapy. CONCLUSIONS: This study utilized significant prognostic indicators and RPA to highlight the importance of age, N-classification, T-classification, comorbidity, and adjuvant therapy in conjunction with American Joint Committee on Cancer staging to improve preoperative counseling.
Authors: Megan E Daly; Quynh-Thu Le; Margaret M Kozak; Peter G Maxim; James D Murphy; Annie Hsu; Billy W Loo; Michael J Kaplan; Nancy J Fischbein; Daniel T Chang Journal: Int J Radiat Oncol Biol Phys Date: 2010-08-02 Impact factor: 7.038
Authors: Moran Amit; Tzu-Chen Yen; Chun-Ta Liao; Pankaj Chaturvedi; Jai Prakash Agarwal; Luiz P Kowalski; Ardalan Ebrahimi; Jonathan R Clark; Matthias Kreppel; Joachim Zöller; Eran Fridman; Villaret A Bolzoni; Jatin P Shah; Yoav Binenbaum; Snehal G Patel; Ziv Gil Journal: Cancer Date: 2013-09-20 Impact factor: 6.860
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Authors: B Singh; M Bhaya; J Stern; J T Roland; M Zimbler; R M Rosenfeld; G Har-El; F E Lucente Journal: Laryngoscope Date: 1997-11 Impact factor: 3.325