Literature DB >> 32993051

The Role and Impact of Extracellular Vesicles in the Modulation and Delivery of Cytokines during Autoimmunity.

Mohammed Tayab Hussain1, Asif Jilani Iqbal2, Lucy Victoria Norling1,3.   

Abstract

Cytokines and extracellular vesicles are two methods of initiating and maintaining cellular crosstalk. The role of cytokines in the initiation, progression, and resolution of inflammation has been well studied and more so, their pathophysiological role in the development of autoimmune disease. In recent years, the impact of extracellular vesicles on the progression of autoimmunity has become more widely appreciated. In this review, we discuss the mechanisms that allow extracellular vesicles of various sources to modulate cytokine production, and release, and how extracellular vesicles might be involved in the direct delivery and modulation of cytokine levels. Moreover, we explore what challenges are faced by current therapies and the promising future for extracellular vesicles as therapeutic agents in conditions driven by immune dysregulation.

Entities:  

Keywords:  autoimmunity; cytokines; exosomes; extracellular vesicles; inflammation

Mesh：

Substances：

Year:  2020        PMID： 32993051      PMCID： PMC7584003          DOI： 10.3390/ijms21197096

Source DB:  PubMed          Journal:  Int J Mol Sci        ISSN： 1422-0067            Impact factor:   5.923


  151 in total

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Journal:  J Immunol       Date:  2011-11-02       Impact factor: 5.422

2.  DEK in the synovium of patients with juvenile idiopathic arthritis: characterization of DEK antibodies and posttranslational modification of the DEK autoantigen.

Authors:  Nirit Mor-Vaknin; Ferdinand Kappes; Amalie E Dick; Maureen Legendre; Catalina Damoc; Seagal Teitz-Tennenbaum; Roland Kwok; Elisa Ferrando-May; Barbara S Adams; David M Markovitz
Journal:  Arthritis Rheum       Date:  2011-02

3.  Control of leukocyte rolling velocity in TNF-alpha-induced inflammation by LFA-1 and Mac-1.

Authors:  Jessica L Dunne; Christie M Ballantyne; Arthur L Beaudet; Klaus Ley
Journal:  Blood       Date:  2002-01-01       Impact factor: 22.113

4.  Different pro-inflammatory profiles of interleukin 1 (IL 1) and tumor necrosis factor (TNF) in an in vivo model of inflammation.

Authors:  M Rampart; W Fiers; W de Smet; A G Herman
Journal:  Agents Actions       Date:  1989-01

5.  Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA.

Authors:  Anne-Claire Duchez; Luc H Boudreau; Gajendra S Naika; James Bollinger; Clémence Belleannée; Nathalie Cloutier; Benoit Laffont; Raifish E Mendoza-Villarroel; Tania Lévesque; Emmanuelle Rollet-Labelle; Matthieu Rousseau; Isabelle Allaeys; Jacques J Tremblay; Patrice E Poubelle; Gérard Lambeau; Marc Pouliot; Patrick Provost; Denis Soulet; Michael H Gelb; Eric Boilard
Journal:  Proc Natl Acad Sci U S A       Date:  2015-06-23       Impact factor: 11.205

6.  What's LPS Got to Do with It? A Role for Gut LPS Variants in Driving Autoimmune and Allergic Disease.

Authors:  Taylor Feehley; Pedro Belda-Ferre; Cathryn R Nagler
Journal:  Cell Host Microbe       Date:  2016-05-11       Impact factor: 21.023

7.  Extracellular Vesicles: Evolving Contributors in Autoimmunity.

Authors:  Stergios Katsiougiannis
Journal:  For Immunopathol Dis Therap       Date:  2015

8.  Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors.

Authors:  D Aderka; H Engelmann; Y Maor; C Brakebusch; D Wallach
Journal:  J Exp Med       Date:  1992-02-01       Impact factor: 14.307

Review 9.  The biology of extracellular microvesicles.

Authors:  Alanna E Sedgwick; Crislyn D'Souza-Schorey
Journal:  Traffic       Date:  2018-03-25       Impact factor: 6.215

10.  Expression of FcRL4 defines a pro-inflammatory, RANKL-producing B cell subset in rheumatoid arthritis.

Authors:  L Yeo; H Lom; M Juarez; M Snow; C D Buckley; A Filer; K Raza; D Scheel-Toellner
Journal:  Ann Rheum Dis       Date:  2014-01-15       Impact factor: 19.103
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  6 in total

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Authors:  Meaghan E Beckner; William R Conkright; Qi Mi; Brian Martin; Amrita Sahu; Shawn D Flanagan; Andrew K Ledford; Martin Wright; Adam Susmarski; Fabrisia Ambrosio; Bradley C Nindl
Journal:  Physiol Genomics       Date:  2022-06-13       Impact factor: 4.297

2.  Circulating exosomal microRNA-18a-5p accentuates intestinal inflammation in Hirschsprung-associated enterocolitis by targeting RORA.

Authors:  Yi Chen; Xiaojian Yuan; Yonglin Li; Jie Chen; Shannan Wu; Amin Jiang; Xuefeng Miao; Qiang Shu
Journal:  Am J Transl Res       Date:  2021-05-15       Impact factor: 4.060

3.  Targeted Lipidomics for Characterization of PUFAs and Eicosanoids in Extracellular Vesicles.

Authors:  Madlen Reinicke; Saikal Shamkeeva; Max Hell; Berend Isermann; Uta Ceglarek; Mitja L Heinemann
Journal:  Nutrients       Date:  2022-03-22       Impact factor: 5.717

Review 4.  The miRNome of Depression.

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Journal:  Int J Mol Sci       Date:  2021-10-20       Impact factor: 5.923

Review 5.  The role of extracellular vesicles in regulating local and systemic inflammation in cardiovascular disease.

Authors:  Lee Ohayon; Xinyi Zhang; Partha Dutta
Journal:  Pharmacol Res       Date:  2021-06-25       Impact factor: 10.334

6.  Cytokine Profile in Plasma Extracellular Vesicles of Parkinson's Disease and the Association with Cognitive Function.

Authors:  Lung Chan; Chen-Chih Chung; Jia-Hung Chen; Ruan-Ching Yu; Chien-Tai Hong
Journal:  Cells       Date:  2021-03-09       Impact factor: 6.600
  6 in total

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