| Literature DB >> 32992328 |
DeAnna J Friedman-Klabanoff1, Mark A Travassos1, Olukemi O Ifeonu2, Sonia Agrawal1, Amed Ouattara1, Andrew Pike1, Jason A Bailey1, Matthew Adams1, Drissa Coulibaly3, Kirsten E Lyke1, Matthew B Laurens1, Shannon Takala-Harrison1, Bourema Kouriba3, Abdoulaye K Kone3, Ogobara K Doumbo3, Jigar J Patel4, Mahamadou A Thera3, Philip L Felgner5, John C Tan4, Christopher V Plowe1, Andrea A Berry1.
Abstract
Circumsporozoite protein (CSP) coats the Plasmodium falciparum sporozoite surface and is a major malaria subunit vaccine target. We measured epitope-specific reactivity to field-derived CSP haplotypes in serum samples from Malian adults and children on a custom peptide microarray. Compared to children, adults showed greater antibody responses and responses to more variants in regions proximal to and within the central repeat region. Children acquired short-lived immunity to an epitope proximal to the central repeat region but not to the central repeat region itself. This approach has the potential to differentiate immunodominant from protective epitope-specific responses when combined with longitudinal infection data.Entities:
Keywords: zzm321990 Plasmodium falciparumzzm321990 ; circumsporozoite protein; malaria; peptide microarray
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Year: 2021 PMID： 32992328 PMCID： PMC8176638 DOI： 10.1093/infdis/jiaa611
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226