| Literature DB >> 32992102 |
Sneha Tandon1, Mary Shago2, Scott Davidson3, Nisha Kanwar3, Fabio Fuligni3, Adam Shlien2, James Whitlock4, Anita Villani4, Oussama Abla4.
Abstract
Infant acute lymphoblastic leukemia (ALL) comprises 2.5%-5% of pediatric ALL with inferior survival compared to older children. A majority of infants (80%) with ALL harbor KMT2A gene rearrangement, which portends a poor prognosis. Approximately 94 different partner genes have been identified to date. The common rearrangements include t(4;11)(q21;q23)KMT2A-AFF1,t(11;19) (q23;p13.3)KMT2A-MLLT1 and t(9;11)(p22;q23)KMT2A-MLLT3. We report a novel translocation t(5;11)(q35;q23)KMT2A-MAML1 in newly diagnosed infant precursor B-ALL. Long-term follow-up and a larger number of patients are needed to better understand its prognostic significance.Entities:
Keywords: Acute leukemia; Infant leukemia; KMT2A-MAML1, Hematologic malignancies
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Year: 2020 PMID： 32992102 DOI： 10.1016/j.cancergen.2020.09.004
Source DB: PubMed Journal: Cancer Genet