Literature DB >> 3299156

Immunohistochemical demonstration of glutamate dehydrogenase in astrocytes.

T Kaneko, H Akiyama, N Mizuno.   

Abstract

A rabbit antiserum was raised against glutamate dehydrogenase (GDH) and applied immunohistochemically to rat brain. GDH-immunoreactive grains were observed mainly in small cells throughout the brain. In most of these cells, coexistence of GDH and glial fibrillary acidic protein was shown by an immunofluorescence method. The results suggest that GDH is primarily an astrocytic enzyme. Possible roles of astrocytic GDH in glutamate and ammonia metabolism are discussed.

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Year:  1987        PMID： 3299156     DOI： 10.1016/0304-3940(87)90581-7

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  4 in total

1.  Amyotrophic lateral sclerosis: glutamate dehydrogenase and transmitter amino acids in the spinal cord.

Authors:  S Malessa; P N Leigh; O Bertel; E Sluga; O Hornykiewicz
Journal:  J Neurol Neurosurg Psychiatry       Date:  1991-11       Impact factor: 10.154

Review 2.  Heterogeneous cellular distribution of glutamate dehydrogenase in brain and in non-neural tissues.

Authors:  Cleanthe Spanaki; Dimitra Kotzamani; Zoe Petraki; Elias Drakos; Andreas Plaitakis
Journal:  Neurochem Res       Date:  2014-01-17       Impact factor: 3.996

3.  Microphotometric determination of enzymes in brain sections. III. Glutamate dehydrogenase.

Authors:  P Kugler
Journal:  Histochemistry       Date:  1990

4.  Widening Spectrum of Cellular and Subcellular Expression of Human GLUD1 and GLUD2 Glutamate Dehydrogenases Suggests Novel Functions.

Authors:  Cleanthe Spanaki; Dimitra Kotzamani; Andreas Plaitakis
Journal:  Neurochem Res       Date:  2016-07-16       Impact factor: 3.996
  4 in total

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