Chia-Yen Lee1,2, Chuen-Chau Chang3,4,5, Chao-Shun Lin3,4,5, Chun-Chieh Yeh6,7, Chaur-Jong Hu8, Ching-Zong Wu2,9, Ta-Liang Chen4,5,10, Chien-Chang Liao3,4,5,11,12. 1. Department of Dentistry, Taiwan Adventist Hospital, Taipei, Taiwan. 2. School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan. 3. Department of Anesthesiology, Taipei Medical University Hospital, Taipei, Taiwan. 4. Anesthesiology and Health Policy Research Center, Taipei Medical University Hospital, Taipei, Taiwan. 5. Department of Anesthesiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. 6. Department of Surgery, China Medical University Hospital, Taichung, Taiwan. 7. Department of Surgery, University of Illinois, Chicago, IL, USA. 8. Department of Neurology, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan. 9. Department of Dentistry, Taipei Medical University Hospital, Taipei, Taiwan. 10. Department of Anesthesiology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. 11. Research Center of Big Data and Meta-Analysis, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. 12. School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan.
Abstract
AIM: We aimed to evaluate the long-term risk of dementia in patients with periodontitis and its associated factors. MATERIALS AND METHODS: Using Taiwan's National Health Insurance Database, we identified 56,018 patients aged ≥50 years with newly diagnosed periodontitis in 2000-2008. A cohort of 56,018 adults without periodontitis was selected for comparison, with matching by age and sex. Both cohorts were followed from 2000 to the end of 2013, and incident dementia was identified during the follow-up period. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of dementia associated with periodontitis were calculated in the multivariate regressions. RESULTS: Periodontitis was associated with dementia risk (HR: 1.79, 95% CI: 1.67-1.93), and the association between periodontitis and dementia risk was significant in men, women, and people aged more than 60 years. Among patients with periodontitis, the use of statins (HR: 0.78, 95% CI: 0.71-0.87), metformin (HR: 0.53, 95% CI: 0.44-0.62), and influenza vaccination (HR: 0.67, 95% CI: 0.61-0.74) were associated with a reduced risk of dementia, while diabetes, mental disorders, and stroke were major significant risk factors. CONCLUSIONS: Periodontitis was a risk factor for dementia, while the use of statins and metformin may reduce the risk of dementia.
AIM: We aimed to evaluate the long-term risk of dementia in patients with periodontitis and its associated factors. MATERIALS AND METHODS: Using Taiwan's National Health Insurance Database, we identified 56,018 patients aged ≥50 years with newly diagnosed periodontitis in 2000-2008. A cohort of 56,018 adults without periodontitis was selected for comparison, with matching by age and sex. Both cohorts were followed from 2000 to the end of 2013, and incident dementia was identified during the follow-up period. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of dementia associated with periodontitis were calculated in the multivariate regressions. RESULTS:Periodontitis was associated with dementia risk (HR: 1.79, 95% CI: 1.67-1.93), and the association between periodontitis and dementia risk was significant in men, women, and people aged more than 60 years. Among patients with periodontitis, the use of statins (HR: 0.78, 95% CI: 0.71-0.87), metformin (HR: 0.53, 95% CI: 0.44-0.62), and influenza vaccination (HR: 0.67, 95% CI: 0.61-0.74) were associated with a reduced risk of dementia, while diabetes, mental disorders, and stroke were major significant risk factors. CONCLUSIONS:Periodontitis was a risk factor for dementia, while the use of statins and metformin may reduce the risk of dementia.
Authors: Avram S Bukhbinder; Yaobin Ling; Omar Hasan; Xiaoqian Jiang; Yejin Kim; Kamal N Phelps; Rosemarie E Schmandt; Albert Amran; Ryan Coburn; Srivathsan Ramesh; Qian Xiao; Paul E Schulz Journal: J Alzheimers Dis Date: 2022 Impact factor: 4.160