PURPOSE: Evaluate the effects of intra-operative leucocyte-poor-platelet-rich plasma (PRP) (type P3-Bβ with endogenous activation) injection in International Cartilage Repair Society (ICRS) grade III knee chondral injuries treated by chondroplasties, to increase and ameliorate the repair tissue. METHODS: Patients were divided into two groups. Group A (control) consisted of 31 patients and Group B (PRP) 33 patients, totaling 64 patients analyzed. Patients also could had associated injuries (meniscal and/or ACL) being equally divided between both groups to avoid bias. PRP was injected at the end of surgery in group B. The patient outcomes were assessed using subjective International Knee Documentation Committee (IKDC) form, Knee Injury and Osteoarthritis Outcome Score (KOOS), and Tegner activity forms, prior to the surgery and three, six, 12, and 24 months after surgery (medium-term follow up). RESULTS:IKDC and KOOS scores showed increase at each evaluation time points after surgery in both groups, but the treated Group (B) showed a higher increase with statistically significant difference. The Tegner activity scores were higher for the treated group only at six and 12 months. CONCLUSION: Based on the subjective IKDC, KOOS, and Tegner scores, those patients affected by ICRS grade III chondral injuries undergoing arthroscopic chondroplasty who were also treated with PRP showed better and faster outcomes than the control group. Independently from the associated injury (meniscal or ACL). This difference could be measured for up to two years.
RCT Entities:
PURPOSE: Evaluate the effects of intra-operative leucocyte-poor-platelet-rich plasma (PRP) (type P3-Bβ with endogenous activation) injection in International Cartilage Repair Society (ICRS) grade III knee chondral injuries treated by chondroplasties, to increase and ameliorate the repair tissue. METHODS:Patients were divided into two groups. Group A (control) consisted of 31 patients and Group B (PRP) 33 patients, totaling 64 patients analyzed. Patients also could had associated injuries (meniscal and/or ACL) being equally divided between both groups to avoid bias. PRP was injected at the end of surgery in group B. The patient outcomes were assessed using subjective International Knee Documentation Committee (IKDC) form, Knee Injury and Osteoarthritis Outcome Score (KOOS), and Tegner activity forms, prior to the surgery and three, six, 12, and 24 months after surgery (medium-term follow up). RESULTS: IKDC and KOOS scores showed increase at each evaluation time points after surgery in both groups, but the treated Group (B) showed a higher increase with statistically significant difference. The Tegner activity scores were higher for the treated group only at six and 12 months. CONCLUSION: Based on the subjective IKDC, KOOS, and Tegner scores, those patients affected by ICRS grade III chondral injuries undergoing arthroscopic chondroplasty who were also treated with PRP showed better and faster outcomes than the control group. Independently from the associated injury (meniscal or ACL). This difference could be measured for up to two years.
Authors: Emilio Lopez-Vidriero; Krista A Goulding; David A Simon; Mikel Sanchez; Donald H Johnson Journal: Arthroscopy Date: 2010-02 Impact factor: 4.772
Authors: Peter Cornelius Kreuz; Jan Philipp Krüger; Sebastian Metzlaff; Undine Freymann; Michaela Endres; Axel Pruss; Wolf Petersen; Christian Kaps Journal: Arthroscopy Date: 2015-05-13 Impact factor: 4.772
Authors: M Del Torto; D Enea; N Panfoli; G Filardo; N Pace; M Chiusaroli Journal: Knee Surg Sports Traumatol Arthrosc Date: 2014-08-31 Impact factor: 4.342
Authors: Timothy E Foster; Brian L Puskas; Bert R Mandelbaum; Michael B Gerhardt; Scott A Rodeo Journal: Am J Sports Med Date: 2009-11 Impact factor: 6.202
Authors: G Filardo; E Kon; A Roffi; B Di Matteo; M L Merli; M Marcacci Journal: Knee Surg Sports Traumatol Arthrosc Date: 2013-11-26 Impact factor: 4.342