Padmamalini Mahendradas1, Thanemozhi Srinivasan1, Ankush Kawali1, Ramesh Venkatesh2, Diganta Hazarika3, Shekar Patil4, Srinivasan Sanjay1, Rohit Shetty5. 1. Department of Uveitis and Ocular Immunology, Narayana Nethralaya, Bangalore, India. 2. Department of Vitreo-retinal Services, Narayana Nethralaya, Bangalore, India. 3. Department of Pathology, HCG Cancer Hospital, Bangalore, India. 4. Department of Medical Oncology, HCG Hospital, Bangalore, India. 5. Department of Cornea and Refractive Surgery, Narayana Nethralaya, Bangalore, India.
Abstract
PURPOSE: To describe the morphological patterns of keratic precipitates (KPs) in vitreoretinal lymphoma (VRL) using in vivo confocal microscopy (IVCM). METHODS: Six eyes of three biopsy-proven VRL patients were included. KPs were identified and analyzed on IVCM. RESULTS: On examination, pigmented KPs in four eyes, white central KPs in two eyes and anterior chamber cells with flare in six eyes and pseudo hypopyon in one eye were identified. A typical floral pattern of KPs on IVCM was noted in all eyes. Three eyes each showed the complete and incomplete floral patterns, respectively. Resolution of KPs on IVCM was noted after chemotherapy. CONCLUSION: In addition to the routinely used clinical and imaging markers like the visual acuity, presence of lymphomatous cells in the vitreous and optical coherence tomography findings, the presence and appearance of KPs on IVCM can also be considered as a useful, diagnostic and treatment monitoring marker in VRL.
PURPOSE: To describe the morphological patterns of keratic precipitates (KPs) in vitreoretinal lymphoma (VRL) using in vivo confocal microscopy (IVCM). METHODS: Six eyes of three biopsy-proven VRL patients were included. KPs were identified and analyzed on IVCM. RESULTS: On examination, pigmented KPs in four eyes, white central KPs in two eyes and anterior chamber cells with flare in six eyes and pseudo hypopyon in one eye were identified. A typical floral pattern of KPs on IVCM was noted in all eyes. Three eyes each showed the complete and incomplete floral patterns, respectively. Resolution of KPs on IVCM was noted after chemotherapy. CONCLUSION: In addition to the routinely used clinical and imaging markers like the visual acuity, presence of lymphomatous cells in the vitreous and optical coherence tomography findings, the presence and appearance of KPs on IVCM can also be considered as a useful, diagnostic and treatment monitoring marker in VRL.