Kenta Sui1, Takehiro Okabayashi1, Yuzo Umeda2, Masahiro Oishi3, Toru Kojima4, Daisuke Sato5, Yoshikatsu Endo6, Tetsuya Ota7, Katsuyoshi Hioki8, Masaru Inagaki9, Tadakazu Matsuda10, Ryuji Hirai11, Masashi Kimura12, Takahito Yagi13, Toshiyoshi Fujiwara13. 1. Department of Gastroenterological Surgery, Kochi Health Sciences Center, Kochi, Japan. 2. Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama, 700-8558, Japan. y.umeda@d9.dion.ne.jp. 3. Department of Surgery, Tottori Municipal Hospital, Tottori, Japan. 4. Department of Gastroenterological Surgery, Okayama Saiseikai General Hospital, Okayama, Japan. 5. Department of Surgery, Hiroshima Citizens Hospital, Hiroshima, Japan. 6. Department of Surgery, Himeji Red Cross Hospital, Himeji, Japan. 7. Department of Surgery, National Okayama Medical Center, Okayama, Japan. 8. Department of Surgery, Fukuyama City Hospital, Fukuyama, Japan. 9. Department of Surgery, National Fukuyama Medical Center, Fukuyama, Japan. 10. Department of Surgery, Tenwakai Matsuda Hospital, Okayama, Japan. 11. Department of Surgery, Himeji Saint Mary's Hospital, Himeji, Japan. 12. Department of Surgery, Matsuyama City Hospital, Matsuyama, Japan. 13. Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama, 700-8558, Japan.
Abstract
OBJECTIVE: The usefulness of the modified Glasgow prognostic score (GPS) as a prognostic tool remains unclear for patients undergoing curative surgery for intrahepatic cholangiocarcinoma (ICC). Therefore, this study investigated the prognostic usefulness of the GPS for patients who underwent ICC surgery. METHOD: All ICC patients who had a curative-intent hepatectomy at 17 institutions between 2000 and 2016 were included. The correlation was assessed between the preoperative GPS and the baseline characteristics of the patients, histopathological parameters, surgical parameters, and the postresection overall survival (OS). RESULT: There were 273 patients who met the eligibility criteria between the years 2000 and 2016. The postoperative OS rates at 1, 3, and 5 years were 83.8%, 56.3%, and 41.5%, respectively (median OS, 47.7 months). A multivariate analysis revealed the factors that were associated with a worse OS, which included an increased GPS (hazard ratio = 1.62; 95% confidence interval [CI]: 1.01-2.53; P = 0.03), an elevated carcinoembryonic antigen level (hazard ratio = 1.60; 95% CI: 1.06-2.41; P = 0.02), an elevated carbohydrate antigen 19-9 level (hazard ratio = 1.55; 95% CI: 1.05-2.30; P = 0.03), undifferentiated carcinoma (hazard ratio = 2.41; 95% CI: 1.56-3.67; P < 0.01), and positive metastasis to the lymph nodes (hazard ratio = 2.54; 95% CI: 1.76-3.67; P < 0.01). In ICC patients after a hepatectomy, an elevated GPS was associated with poorer OS, even if the tumour factors that affected GPS were eliminated by propensity-score matching. CONCLUSION: Preoperative GPS can be useful to predict the postoperative outcomes of ICC patients. Therefore, this relatively simple and inexpensive scoring system can be utilized to further refine patient stratification as well as to predict survival.
OBJECTIVE: The usefulness of the modified Glasgow prognostic score (GPS) as a prognostic tool remains unclear for patients undergoing curative surgery for intrahepatic cholangiocarcinoma (ICC). Therefore, this study investigated the prognostic usefulness of the GPS for patients who underwent ICC surgery. METHOD: All ICC patients who had a curative-intent hepatectomy at 17 institutions between 2000 and 2016 were included. The correlation was assessed between the preoperative GPS and the baseline characteristics of the patients, histopathological parameters, surgical parameters, and the postresection overall survival (OS). RESULT: There were 273 patients who met the eligibility criteria between the years 2000 and 2016. The postoperative OS rates at 1, 3, and 5 years were 83.8%, 56.3%, and 41.5%, respectively (median OS, 47.7 months). A multivariate analysis revealed the factors that were associated with a worse OS, which included an increased GPS (hazard ratio = 1.62; 95% confidence interval [CI]: 1.01-2.53; P = 0.03), an elevated carcinoembryonic antigen level (hazard ratio = 1.60; 95% CI: 1.06-2.41; P = 0.02), an elevated carbohydrate antigen 19-9 level (hazard ratio = 1.55; 95% CI: 1.05-2.30; P = 0.03), undifferentiated carcinoma (hazard ratio = 2.41; 95% CI: 1.56-3.67; P < 0.01), and positive metastasis to the lymph nodes (hazard ratio = 2.54; 95% CI: 1.76-3.67; P < 0.01). In ICC patients after a hepatectomy, an elevated GPS was associated with poorer OS, even if the tumour factors that affected GPS were eliminated by propensity-score matching. CONCLUSION: Preoperative GPS can be useful to predict the postoperative outcomes of ICC patients. Therefore, this relatively simple and inexpensive scoring system can be utilized to further refine patient stratification as well as to predict survival.
Authors: Andreas A Schnitzbauer; Johannes Eberhard; Fabian Bartsch; Stefan M Brunner; Güralp O Ceyhan; Dirk Walter; Helmut Fries; Sabine Hannes; Andreas Hecker; Jun Li; Karl Oldhafer; Nuh Rahbari; Falk Rauchfuss; Hans J Schlitt; Utz Settmacher; Gregor Stavrou; Jürgen Weitz; Hauke Lang; Wolf O Bechstein; Felix Rückert Journal: Ann Surg Oncol Date: 2019-10-23 Impact factor: 5.344