Literature DB >> 32988821

Captisol and GS-704277, but Not GS-441524, Are Credible Mediators of Remdesivir's Nephrotoxicity.

Victoria C Yan1, Florian L Muller2.   

Abstract

Entities:  

Keywords:  GS-441524; drug metabolism; prodrug; remdesivir; renal clearance

Mesh：

Substances：

Year:  2020        PMID： 32988821      PMCID： PMC7674034          DOI： 10.1128/AAC.01920-20

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


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  12 in total

1.  Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses.

Authors:  Timothy P Sheahan; Amy C Sims; Rachel L Graham; Vineet D Menachery; Lisa E Gralinski; James B Case; Sarah R Leist; Krzysztof Pyrc; Joy Y Feng; Iva Trantcheva; Roy Bannister; Yeojin Park; Darius Babusis; Michael O Clarke; Richard L Mackman; Jamie E Spahn; Christopher A Palmiotti; Dustin Siegel; Adrian S Ray; Tomas Cihlar; Robert Jordan; Mark R Denison; Ralph S Baric
Journal:  Sci Transl Med       Date:  2017-06-28       Impact factor: 17.956

Review 2.  Cyclodextrins.

Authors:  Valentino J Stella; Quanren He
Journal:  Toxicol Pathol       Date:  2008-01       Impact factor: 1.902

3.  Pharmacokinetics of remdesivir and GS-441524 in two critically ill patients who recovered from COVID-19.

Authors:  Massimo Tempestilli; Priscilla Caputi; Valeria Avataneo; Stefania Notari; Olindo Forini; Laura Scorzolini; Luisa Marchioni; Tommaso Ascoli Bartoli; Concetta Castilletti; Eleonora Lalle; Maria R Capobianchi; Emanuele Nicastri; Antonio D'Avolio; Giuseppe Ippolito; Chiara Agrati
Journal:  J Antimicrob Chemother       Date:  2020-10-01       Impact factor: 5.790

4.  Safety, Tolerability, and Pharmacokinetics of Remdesivir, An Antiviral for Treatment of COVID-19, in Healthy Subjects.

Authors:  Rita Humeniuk; Anita Mathias; Huyen Cao; Anu Osinusi; Gong Shen; Estelle Chng; John Ling; Amanda Vu; Polina German
Journal:  Clin Transl Sci       Date:  2020-08-05       Impact factor: 4.689

5.  Clinical Pharmacokinetics of Sulfobutylether-β-Cyclodextrin in Patients With Varying Degrees of Renal Impairment.

Authors:  Randall K Hoover; Harry Alcorn; Laura Lawrence; Susan K Paulson; Megan Quintas; David R Luke; Sue K Cammarata
Journal:  J Clin Pharmacol       Date:  2018-03-26       Impact factor: 3.126

6.  Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses.

Authors:  Dustin Siegel; Hon C Hui; Edward Doerffler; Michael O Clarke; Kwon Chun; Lijun Zhang; Sean Neville; Ernest Carra; Willard Lew; Bruce Ross; Queenie Wang; Lydia Wolfe; Robert Jordan; Veronica Soloveva; John Knox; Jason Perry; Michel Perron; Kirsten M Stray; Ona Barauskas; Joy Y Feng; Yili Xu; Gary Lee; Arnold L Rheingold; Adrian S Ray; Roy Bannister; Robert Strickley; Swami Swaminathan; William A Lee; Sina Bavari; Tomas Cihlar; Michael K Lo; Travis K Warren; Richard L Mackman
Journal:  J Med Chem       Date:  2017-02-14       Impact factor: 7.446

7.  Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys.

Authors:  Travis K Warren; Robert Jordan; Michael K Lo; Adrian S Ray; Richard L Mackman; Veronica Soloveva; Dustin Siegel; Michel Perron; Roy Bannister; Hon C Hui; Nate Larson; Robert Strickley; Jay Wells; Kelly S Stuthman; Sean A Van Tongeren; Nicole L Garza; Ginger Donnelly; Amy C Shurtleff; Cary J Retterer; Dima Gharaibeh; Rouzbeh Zamani; Tara Kenny; Brett P Eaton; Elizabeth Grimes; Lisa S Welch; Laura Gomba; Catherine L Wilhelmsen; Donald K Nichols; Jonathan E Nuss; Elyse R Nagle; Jeffrey R Kugelman; Gustavo Palacios; Edward Doerffler; Sean Neville; Ernest Carra; Michael O Clarke; Lijun Zhang; Willard Lew; Bruce Ross; Queenie Wang; Kwon Chun; Lydia Wolfe; Darius Babusis; Yeojin Park; Kirsten M Stray; Iva Trancheva; Joy Y Feng; Ona Barauskas; Yili Xu; Pamela Wong; Molly R Braun; Mike Flint; Laura K McMullan; Shan-Shan Chen; Rachel Fearns; Swami Swaminathan; Douglas L Mayers; Christina F Spiropoulou; William A Lee; Stuart T Nichol; Tomas Cihlar; Sina Bavari
Journal:  Nature       Date:  2016-03-02       Impact factor: 49.962

8.  Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2.

Authors:  Brandi N Williamson; Friederike Feldmann; Benjamin Schwarz; Kimberly Meade-White; Danielle P Porter; Jonathan Schulz; Neeltje van Doremalen; Ian Leighton; Claude Kwe Yinda; Lizzette Pérez-Pérez; Atsushi Okumura; Jamie Lovaglio; Patrick W Hanley; Greg Saturday; Catharine M Bosio; Sarah Anzick; Kent Barbian; Tomas Cihlar; Craig Martens; Dana P Scott; Vincent J Munster; Emmie de Wit
Journal:  Nature       Date:  2020-06-09       Impact factor: 49.962
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  4 in total

Review 1.  Beyond the vaccines: a glance at the small molecule and peptide-based anti-COVID19 arsenal.

Authors:  Kunal Nepali; Ram Sharma; Sachin Sharma; Amandeep Thakur; Jing-Ping Liou
Journal:  J Biomed Sci       Date:  2022-09-06       Impact factor: 12.771

2.  Liver and kidney function in patients with Covid-19 treated with remdesivir.

Authors:  Sylvia A van Laar; Mark G J de Boer; Kim B Gombert-Handoko; Henk-Jan Guchelaar; Juliette Zwaveling
Journal:  Br J Clin Pharmacol       Date:  2021-05-04       Impact factor: 3.716

3.  A Valid Warning or Clinical Lore: an Evaluation of Safety Outcomes of Remdesivir in Patients with Impaired Renal Function from a Multicenter Matched Cohort.

Authors:  Tyler W Ackley; Dayna McManus; Jeffrey E Topal; Brian Cicali; Sunish Shah
Journal:  Antimicrob Agents Chemother       Date:  2021-01-20       Impact factor: 5.191

4.  Reply to Yan and Muller, "Captisol and GS-704277, but Not GS-441524, Are Credible Mediators of Remdesivir's Nephrotoxicity".

Authors:  Minh Patrick Lê; Christine Le Beller; Quentin Le Hingrat; Pierre Jaquet; Paul-Henri Wicky; Vincent Bunel; Laurent Massias; Benoit Visseaux; Jonathan Messika; Diane Descamps; Hervé Mal; Jean-François Timsit; Gilles Peytavin
Journal:  Antimicrob Agents Chemother       Date:  2020-11-17       Impact factor: 5.191
  4 in total

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