Ana Luiza Oliveira Corrêa Roza1, Emanuel Mendes Sousa2, Amanda Almeida Leite1, Gleyson Kleber Amaral-Silva1, Thayná Melo de Lima Morais1, Vivian Petersen Wagner1, Lauren Frenzel Schuch1, Ana Carolina Uchoa Vasconcelos3, José Alcides Almeida de Arruda4, Ricardo Alves Mesquita4, Felipe Paiva Fonseca5, Aline Corrêa Abrahão2, Michelle Agostini2, Bruno Augusto Benevenuto de Andrade2, Ericka Janine Dantas da Silveira6, René Martínez-Flores7, Benjamin Martínez Rondanelli8, Javier Alberdi-Navarro9, Liam Robinson10, Constanza Marin11, José Narciso Rosa Assunção Júnior12, Renato Valiati13, Eduardo Rodrigues Fregnani14, Alan Roger Santos-Silva1, Marcio Ajudarte Lopes1, Keith D Hunter15, Syed Ali Khurram11, Paul M Speight11, Adalberto Mosqueda-Taylor16, Willie F P van Heerden10, Román Carlos17, John M Wright18, Oslei Paes de Almeida1, Mário José Romañach2, Pablo Agustin Vargas19. 1. Oral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), São Paulo, Brazil. 2. Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil. 3. Diagnostic Center of Oral Diseases, School of Dentistry, Federal University of Pelotas (UFPel), Pelotas, Brazil. 4. Department of Oral Surgery and Pathology, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil. 5. Oral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), São Paulo, Brazil; Department of Oral Surgery and Pathology, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil; Department of Oral Pathology and Oral Biology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa. 6. Post-Graduate Program in Dentistry Sciences, Dentistry Department, Federal University of Rio Grande do Norte (UFRN), Natal, Brazil. 7. Department of Oral Pathology and Oral Medicine, Dentistry Faculty, Andrés Bello University, Viña del Mar, Chile. 8. Department of Oral Pathology and Oral Medicine, Dentistry Faculty, Mayor University, Santiago, Chile. 9. Oral Medicine and Oral and Maxillofacial Pathology Unit, Dental Clinic Service, Department of Stomatology II, University of the Basque Country (UPV/EHU), Leioa, Spain. 10. Department of Oral Pathology and Oral Biology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa. 11. Academic Unit of Oral and Maxillofacial Medicine and Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, UK. 12. School of Dentistry, Metropolitan University of Santos (UNIMES), Santos, Brazil. 13. School of Dentistry, Planalto Catarinense University (UNIPLAC), Lages, Brazil. 14. Centro de Oncologia Molecular, Hospital Sírio Libanês, São Paulo, Brazil. 15. Academic Unit of Oral and Maxillofacial Medicine and Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, UK; Department of Oral Pathology and Oral Biology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa. 16. Departamento de Atención a la Salud, Universidad Autónoma Metropolitana Xochimilco, Mexico City, Mexico. 17. Pathology Section, Centro Clínico de Cabeza y Cuello/Hospital Herrera Llerandi, Guatemala City, Guatemala. 18. Department of Diagnostic Sciences, Texas A&M University College of Dentistry, College Station, TX, USA. 19. Oral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), São Paulo, Brazil; Department of Oral Pathology and Oral Biology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa. Electronic address: pavargas@unicamp.br.
Abstract
OBJECTIVE: The aim of this study was to report the clinicopathologic features of 62 cases of central odontogenic fibroma (COdF). STUDY DESIGN: Clinical and radiographic data were collected from the records of 13 oral pathology laboratories. All cases were microscopically reviewed, considering the current World Health Organization classification of tumors and were classified according to histopathologic features. RESULTS: There were 43 females and 19 males (average age 33.9 years; range 8-63 years). Clinically, COdF lesions appeared as asymptomatic swellings, occurring similarly in the maxilla (n = 33) and the mandible (n = 29); 9 cases exhibited palatal depression. Imaging revealed well-defined, interradicular unilocular (n = 27), and multilocular (n = 12) radiolucencies, with displacement of contiguous teeth (55%) and root resorption (46.4%). Microscopically, classic features of epithelial-rich (n = 33), amyloid (n = 10), associated giant cell lesion (n = 7), ossifying (n = 6), epithelial-poor (n = 3), and granular cell (n = 3) variants were seen. Langerhans cells were highlighted by CD1a staining in 17 cases. Most patients underwent conservative surgical treatments, with 1 patient experiencing recurrence. CONCLUSIONS: To the best of our knowledge, this study represents the largest clinicopathologic study of COdF. Most cases appeared as locally aggressive lesions located in tooth-bearing areas in middle-aged women. Inactive-appearing odontogenic epithelium is usually observed within a fibrous/fibromyxoid stroma, occasionally exhibiting amyloid deposits, multinucleated giant cells, or granular cells.
OBJECTIVE: The aim of this study was to report the clinicopathologic features of 62 cases of central odontogenic fibroma (COdF). STUDY DESIGN: Clinical and radiographic data were collected from the records of 13 oral pathology laboratories. All cases were microscopically reviewed, considering the current World Health Organization classification of tumors and were classified according to histopathologic features. RESULTS: There were 43 females and 19 males (average age 33.9 years; range 8-63 years). Clinically, COdF lesions appeared as asymptomatic swellings, occurring similarly in the maxilla (n = 33) and the mandible (n = 29); 9 cases exhibited palatal depression. Imaging revealed well-defined, interradicular unilocular (n = 27), and multilocular (n = 12) radiolucencies, with displacement of contiguous teeth (55%) and root resorption (46.4%). Microscopically, classic features of epithelial-rich (n = 33), amyloid (n = 10), associated giant cell lesion (n = 7), ossifying (n = 6), epithelial-poor (n = 3), and granular cell (n = 3) variants were seen. Langerhans cells were highlighted by CD1a staining in 17 cases. Most patients underwent conservative surgical treatments, with 1 patient experiencing recurrence. CONCLUSIONS: To the best of our knowledge, this study represents the largest clinicopathologic study of COdF. Most cases appeared as locally aggressive lesions located in tooth-bearing areas in middle-aged women. Inactive-appearing odontogenic epithelium is usually observed within a fibrous/fibromyxoid stroma, occasionally exhibiting amyloid deposits, multinucleated giant cells, or granular cells.