Inderbir Singh1, Ajay Kumar Thakur1, Rajni Bala1, Reecha Madan1.
Abstract
BACKGROUND: SeDeM (Sediment Delivery Model) expert system is a preformulation tool employed for evaluating direct compression suitability of various excipients. SeDeM is a 12 parameters derived diagram and SeDeM-ODT (Sediment Delivery Model-Orodispersible tablets) is a 15 parameters derived diagram that can be used as a research tool for reducing the product development time. The best possible excipients for a specified pharmaceutical active ingredient could be screened for direct compression suitability.
OBJECTIVE: SeDeM expert system has been successfully used and implemented for characterizing galenic properties of pharmaceutical excipients, direct compression suitability of excipients, development of ODT formulations, development of sustained-release formulations, and development of tablets of taste-masked drugs.
CONCLUSION: In the present review paper, the development and applications of SeDeM and SeDeMODT systems have been discussed in detail. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
BACKGROUND: SeDeM (Sediment Delivery Model) expert system is a preformulation tool employed for evaluating direct compression suitability of various excipients. SeDeM is a 12 parameters derived diagram and SeDeM-ODT (Sediment Delivery Model-Orodispersible tablets) is a 15 parameters derived diagram that can be used as a research tool for reducing the product development time. The best possible excipients for a specified pharmaceutical active ingredient could be screened for direct compression suitability.
OBJECTIVE: SeDeM expert system has been successfully used and implemented for characterizing galenic properties of pharmaceutical excipients, direct compression suitability of excipients, development of ODT formulations, development of sustained-release formulations, and development of tablets of taste-masked drugs.
CONCLUSION: In the present review paper, the development and applications of SeDeM and SeDeMODT systems have been discussed in detail. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
Entities:
Keywords:
SeDeM; SeDeM-ODT; application; direct compression; excipients; tablets
Year: 2021
PMID： 32988362 DOI： 10.2174/2589977512666200928113716
Source DB: PubMed Journal: Curr Drug Res Rev ISSN： 2589-9775