Yasmin Vendramini1, Alexandre Salles2, Fernando Freitas Portella1, Myrian Camara Brew1, Liviu Steier3, José Antonio Poli de Figueiredo4, Caren Serra Bavaresco1. 1. Brazilian Lutheran University, ULBRA, Dental School, Av. Farroupila, 8001 Bairro São José, Canoas, RS, CEP 92425-020, Brazil. 2. Serra Gaúcha University Center, FSG, Dental School, R. Os Dezoito Do Forte, 2366 São Pelegrino, Caxias do Sul, RS, CEP 95020-472, Brazil. 3. University of Pennsylvania, Dental School, Department of Preventive and Restorative Sciences, 240 S 40th St, Philadelphia, PA, 19104, USA. 4. Federal University of Rio Grande do Sul, UFRGS, Institute of Health Basic Sciences, ICBS R, Sarmento Leite 500 sala 134, Farroupilha, Porto Alegre, RS, CEP 90050-170, Brazil. Electronic address: poli.figueiredo@outlook.com.
Abstract
BACKGROUND: Antimicrobial photodynamic therapy (A-PDT), is one of the adjunctive therapies developed to improve the effectiveness of root canal disinfection.. The aim of this study was to analyze the antimicrobial effect of PDT on intracanal biofilm. METHODS: Two reviewers conducted a literature search in PubMed, MEDLINE, Lilacs, SciELO, EMBASE and Google Scholar using the following search strategy: photochemotherapy "[Mesh] OR (photodynamic therapy) AND" dental plaque "[Mesh] OR (dental biofilm) AND (root canal). The following data were collected: publication year, author's name, study site, type of study, participant number, type of photosensitizer, type of laser, method of data collection, application time and results. Study quality was assessed using the Methodological Index for Non-Randomized Studies (MINORS). RESULTS: After selection based on title, abstract and full text, 27 studies were included in this systematic review. PDT reduced bacterial viability in most studies when combined with conventional endodontic techniques. CONCLUSION: PDT reduced bacterial counts in most studies, especially when used as an adjunct to the conventional endodontic technique to treat refractory infection. However, PDT effects on in vitro bacterial biofilm were not accurately quantified because of the numerous biases in the studies reviewed.
BACKGROUND: Antimicrobial photodynamic therapy (A-PDT), is one of the adjunctive therapies developed to improve the effectiveness of root canal disinfection.. The aim of this study was to analyze the antimicrobial effect of PDT on intracanal biofilm. METHODS: Two reviewers conducted a literature search in PubMed, MEDLINE, Lilacs, SciELO, EMBASE and Google Scholar using the following search strategy: photochemotherapy "[Mesh] OR (photodynamic therapy) AND" dental plaque "[Mesh] OR (dental biofilm) AND (root canal). The following data were collected: publication year, author's name, study site, type of study, participant number, type of photosensitizer, type of laser, method of data collection, application time and results. Study quality was assessed using the Methodological Index for Non-Randomized Studies (MINORS). RESULTS: After selection based on title, abstract and full text, 27 studies were included in this systematic review. PDT reduced bacterial viability in most studies when combined with conventional endodontic techniques. CONCLUSION: PDT reduced bacterial counts in most studies, especially when used as an adjunct to the conventional endodontic technique to treat refractory infection. However, PDT effects on in vitro bacterial biofilm were not accurately quantified because of the numerous biases in the studies reviewed.