Literature DB >> 32986806

Asymptomatic carriage rates and case fatality of SARS-CoV-2 infection in residents and staff in Irish nursing homes.

Sean P Kennelly1, Adam H Dyer1, Claire Noonan1, Ruth Martin2, Siobhan M Kennelly2, Alan Martin3, Desmond O'Neill1, Aoife Fallon1.   

Abstract

BACKGROUND: SARS-CoV-2 has disproportionately affected nursing homes (NH). In Ireland, the first NH case COVID-19 occurred on 16 March 2020. A national point-prevalence testing programme of all NH residents and staff took place (18 April 2020 to 5 May 2020). AIMS: to examine characteristics of NHs across three Irish Community Health Organisations, proportions with COVID-19 outbreaks, staff and resident infection rates symptom profile and resident case fatality.
METHODS: in total, 45 NHs surveyed, requesting details on occupancy, size, COVID-19 outbreak, outbreak timing, total symptomatic/asymptomatic cases and outcomes for residents from 29 February 2020 to 22 May 2020.
RESULTS: surveys were returned from 62.2% (28/45) of NHs (2,043 residents, 2,303 beds). Three-quarters (21/28) had COVID-19 outbreaks (1,741 residents, 1,972 beds). Median time from first COVID-19 case in Ireland to first case in these NHs was 27.0 days. Resident incidence was 43.9% (764/1,741)-40.8% (710/1,741) laboratory confirmed, with 27.2% (193/710) asymptomatic and 3.1% (54/1,741) clinically suspected. Resident case fatality was 27.6% (211/764) for combined laboratory-confirmed/clinically suspected COVID-19. Similar proportions of residents in NHs with 'early-stage' (<28 days) versus 'later-stage' outbreaks developed COVID-19. Lower proportions of residents in 'early' outbreak NHs had recovered compared with those with 'late' outbreaks (37.4 versus 61.7%; χ2 = 56.9, P < 0.001). Of 395 NH staff across 12 sites with confirmed COVID-19, 24.7% (99/398) were asymptomatic. There was a significant correlation between the proportion of staff with symptomatic COVID-19 and resident numbers with confirmed/suspected COVID-19 (Spearman's rho = 0.81, P < 0.001).
CONCLUSION: this study demonstrates the significant impact of COVID-19 on the NH sector. Systematic point-prevalence testing is necessary to reduce risk of transmission from asymptomatic carriers and manage outbreaks in this setting.
© The Author(s) 2020. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Entities:  

Keywords:  COVID-19; nursing home; older people; residents; staff; symptoms

Year:  2021        PMID: 32986806      PMCID: PMC7543256          DOI: 10.1093/ageing/afaa220

Source DB:  PubMed          Journal:  Age Ageing        ISSN: 0002-0729            Impact factor:   10.668


  18 in total

1.  Impact of non-pharmaceutical interventions on SARS-CoV-2 outbreaks in English care homes: a modelling study.

Authors:  Alicia Rosello; Rosanna C Barnard; David R M Smith; Stephanie Evans; Fiona Grimm; Nicholas G Davies; Sarah R Deeny; Gwenan M Knight; W John Edmunds
Journal:  BMC Infect Dis       Date:  2022-04-01       Impact factor: 3.090

2.  Health impact of the first and second wave of COVID-19 and related restrictive measures among nursing home residents: a scoping review.

Authors:  Marjolein E A Verbiest; Annerieke Stoop; Aukelien Scheffelaar; Meriam M Janssen; Leonieke C van Boekel; Katrien G Luijkx
Journal:  BMC Health Serv Res       Date:  2022-07-15       Impact factor: 2.908

3.  Comparison of molecular testing strategies for COVID-19 control: a mathematical modelling study.

Authors:  Nicholas C Grassly; Margarita Pons-Salort; Edward P K Parker; Peter J White; Neil M Ferguson
Journal:  Lancet Infect Dis       Date:  2020-08-18       Impact factor: 25.071

4.  Infection and transmission of SARS-CoV-2 in London care homes reporting no cases or outbreaks of COVID-19: Prospective observational cohort study, England 2020.

Authors:  Anna Jeffery-Smith; Kate Dun-Campbell; Roshni Janarthanan; Jonathan Fok; Emma Crawley-Boevey; Amoolya Vusirikala; Elena Fernandez Ruiz De Olano; Marina Sanchez Perez; Suzanne Tang; Thomas Aj Rowland; Edward Wynne-Evans; Anita Bell; Bharat Patel; Zahin Amin-Chowdhury; Felicity Aiano; Karthik Paranthaman; Thomas Ma; Maria Saavedra-Campos; Joanna Ellis; Angie Lackenby; Heather Whitaker; Richard Myers; Katja Höschler; Kevin Brown; Mary E Ramsay; Nandini Shetty; J Yimmy Chow; Shamez Ladhani; Maria Zambon
Journal:  Lancet Reg Health Eur       Date:  2021-01-22

5.  Epidemiology and clinical features of COVID-19 outbreaks in aged care facilities: A systematic review and meta-analysis.

Authors:  Mohammad Rashidul Hashan; Nicolas Smoll; Catherine King; Hannah Ockenden-Muldoon; Jacina Walker; Andre Wattiaux; Julieanne Graham; Robert Booy; Gulam Khandaker
Journal:  EClinicalMedicine       Date:  2021-03-01

6.  Care-home outbreaks of COVID-19 in Scotland March to May 2020: National linked data cohort analysis.

Authors:  Jennifer Kirsty Burton; Megan McMinn; James E Vaughan; Jacques Fleuriot; Bruce Guthrie
Journal:  Age Ageing       Date:  2021-09-11       Impact factor: 10.668

7.  Previous SARS-CoV-2 Infection, Age, and Frailty Are Associated With 6-Month Vaccine-Induced Anti-Spike Antibody Titer in Nursing Home Residents.

Authors:  Adam H Dyer; Claire Noonan; Matt McElheron; Isabella Batten; Conor Reddy; Emma Connolly; Rachel Pierpoint; Caroline Murray; Ann Leonard; Catriona Higgins; Phyllis Reilly; Gerard Boran; Thomas Phelan; William McCormack; Desmond O'Neill; Aoife Fallon; Gareth Brady; Cliona O'Farrelly; Nollaig M Bourke; Sean P Kennelly
Journal:  J Am Med Dir Assoc       Date:  2022-01-11       Impact factor: 7.802

8.  Outbreak of SARS-CoV-2 Lineage 20I/501Y.V1 in a Nursing Home Underlines the Crucial Role of Vaccination in Both Residents and Staff.

Authors:  Andrea Orsi; Alexander Domnich; Vanessa De Pace; Valentina Ricucci; Patrizia Caligiuri; Livio Bottiglieri; Rosanna Vagge; Maurizio A Cavalleri; Francesco Orlandini; Bianca Bruzzone; Giancarlo Icardi
Journal:  Vaccines (Basel)       Date:  2021-06-02

9.  Reducing Morbidity and Mortality Rates from COVID-19, Influenza and Pneumococcal Illness in Nursing Homes and Long-Term Care Facilities by Vaccination and Comprehensive Infection Control Interventions.

Authors:  Roger E Thomas
Journal:  Geriatrics (Basel)       Date:  2021-05-08

10.  The impact of coronavirus disease 2019 (COVID-19) on older adults with an intellectual disability during the first wave of the pandemic in Ireland.

Authors:  Mary McCarron; Darren McCausland; Retha Luus; Andrew Allen; Fintan Sheerin; Eilish Burke; Eimear McGlinchy; Fidelma Flannery; Philip McCallion
Journal:  HRB Open Res       Date:  2021-12-13
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.