PURPOSE: To evaluate the associations between computed tomography (CT) imaging features extracted from the structured American Pancreatic Association (APA)/Society of Abdominal Radiology (SAR) template and overall survival in patients with resected pancreatic ductal adenocarcinoma (PDAC). METHODS: This retrospective analysis included consecutive patients with PDAC who consented to genomic tumor testing and underwent preoperative imaging and curative intent surgical resection from December 2006 to July 2017. Two radiologists assessed preoperative CT imaging using the APA/SAR PDAC-reporting template. Univariable associations between overall survival and imaging variables were evaluated using Cox proportional hazards regression. RESULTS: The study included 168 patients (66 years ± 11; 91 women). 126/168 patients (75%) received upfront surgical resection whereas 42/168 (25%) received neoadjuvant therapy prior to surgical resection. In the entire cohort, features associated with decreased overall survival were tumor arterial contact of any kind (hazard ratio (HR) 1.89, 95% CI 1.13-3.14, p = 0.020), tumor contact with the common hepatic artery (HR 2.33, 95% CI 1.35-4.04, p = 0.009), and portal vein deformity (HR 3.22, 95% CI 1.63-6.37, p = 0.003). In the upfront surgical group, larger tumor size was associated with decreased overall survival (HR 2.30, 95% CI 1.19-4.42, p = 0.013). In the neoadjuvant therapy group, the presence of venous collaterals was the only feature associated with decreased overall survival (HR 2.28, 95% CI 1.04-4.99, p = 0.042). CONCLUSION: The application of the APA/SAR pancreatic adenocarcinoma reporting template may identify predictors of survival that can aid in preoperative stratification of patients.
PURPOSE: To evaluate the associations between computed tomography (CT) imaging features extracted from the structured American Pancreatic Association (APA)/Society of Abdominal Radiology (SAR) template and overall survival in patients with resected pancreatic ductal adenocarcinoma (PDAC). METHODS: This retrospective analysis included consecutive patients with PDAC who consented to genomic tumor testing and underwent preoperative imaging and curative intent surgical resection from December 2006 to July 2017. Two radiologists assessed preoperative CT imaging using the APA/SAR PDAC-reporting template. Univariable associations between overall survival and imaging variables were evaluated using Cox proportional hazards regression. RESULTS: The study included 168 patients (66 years ± 11; 91 women). 126/168 patients (75%) received upfront surgical resection whereas 42/168 (25%) received neoadjuvant therapy prior to surgical resection. In the entire cohort, features associated with decreased overall survival were tumor arterial contact of any kind (hazard ratio (HR) 1.89, 95% CI 1.13-3.14, p = 0.020), tumor contact with the common hepatic artery (HR 2.33, 95% CI 1.35-4.04, p = 0.009), and portal vein deformity (HR 3.22, 95% CI 1.63-6.37, p = 0.003). In the upfront surgical group, larger tumor size was associated with decreased overall survival (HR 2.30, 95% CI 1.19-4.42, p = 0.013). In the neoadjuvant therapy group, the presence of venous collaterals was the only feature associated with decreased overall survival (HR 2.28, 95% CI 1.04-4.99, p = 0.042). CONCLUSION: The application of the APA/SAR pancreatic adenocarcinoma reporting template may identify predictors of survival that can aid in preoperative stratification of patients.
Authors: Stephanie T Chang; R Brooke Jeffrey; Bhavik N Patel; Michael A DiMaio; Jarrett Rosenberg; Juergen K Willmann; Eric W Olcott Journal: Radiology Date: 2016-07-20 Impact factor: 11.105
Authors: Hop S Tran Cao; Alpana Balachandran; Huamin Wang; Graciela M Nogueras-González; Christina E Bailey; Jeffrey E Lee; Peter W T Pisters; Douglas B Evans; Gauri Varadhachary; Christopher H Crane; Thomas A Aloia; Jean-Nicolas Vauthey; Jason B Fleming; Matthew H G Katz Journal: J Gastrointest Surg Date: 2013-10-16 Impact factor: 3.452
Authors: Geoffrey M Kozak; Jeffrey D Epstein; Sandeep P Deshmukh; Benjamin B Scott; Scott W Keith; Harish Lavu; Charles J Yeo; Jordan M Winter Journal: J Gastrointest Surg Date: 2017-11-14 Impact factor: 3.452
Authors: Nils D Arvold; Andrzej Niemierko; Harvey J Mamon; Carlos Fernandez-del Castillo; Theodore S Hong Journal: Int J Radiat Oncol Biol Phys Date: 2010-08-12 Impact factor: 7.038
Authors: Jin Hee Kim; Seong Ho Park; Eun Sil Yu; Myung-Hwan Kim; Jihun Kim; Jae Ho Byun; Seung Soo Lee; Hye Jeon Hwang; Jae-Yeon Hwang; Sang Soo Lee; Moon-Gyu Lee Journal: Radiology Date: 2010-08-09 Impact factor: 11.105
Authors: Min Young Park; Sang Hyun Shin; Ki Byung Song; DaeWook Hwang; Jae Hoon Lee; Young-Joo Lee; Song Cheol Kim Journal: Ann Hepatobiliary Pancreat Surg Date: 2019-02-28
Authors: Diego A S Toesca; R Brooke Jeffrey; Rie von Eyben; Erqi L Pollom; Peter D Poullos; George A Poultsides; George A Fisher; Brendan C Visser; Albert C Koong; Daniel T Chang Journal: Pancreas Date: 2019 May/Jun Impact factor: 3.327