| Literature DB >> 3298525 |
P W Kantoff, A P Gillio, J R McLachlin, C Bordignon, M A Eglitis, N A Kernan, R C Moen, D B Kohn, S F Yu, E Karson.
Abstract
Primate bone marrow cells were infected with a retroviral vector carrying the genes for human adenosine deaminase (h-ADA) and bacterial neomycin resistance (neor). The infected cells were infused back into the lethally irradiated donor animals. Several monkeys fully reconstituted and were shown to express the h-ADA and neor genes at low levels in their recirculating hematopoietic cells for short periods of time.Entities:
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Year: 1987 PMID: 3298525 PMCID: PMC2188649 DOI: 10.1084/jem.166.1.219
Source DB: PubMed Journal: J Exp Med ISSN: 0022-1007 Impact factor: 14.307