| Literature DB >> 32985165 |
Jie Li1, Junyu Xu1,2, Jianhong Luo1.
Abstract
More and more evidences support that the abnormality of GABAergic interneurons is associated with autism spectrum disorders (ASD), epilepsy, schizophrenia and other neurodevelopmental disorders. In recent years, numerous drugs have been developed to regulate ion channels and receptors in GABAergic interneurons, including sodium channels and N-methyl-D-aspartate (NMDA) receptors. The activators of Na+ channel can enhance the action potential of GABAergic interneurons by reducing the inactivation of Na+ channel. NMDA receptor, as a potential therapeutic target of ASD, can restore the NMDA function of GABAergic interneurons, which would be used to treat behavioral defects. In addition, there are many ion channels and receptors on GABAergic interneurons related to ASD. This article reviews GABAergic interneurons in the pathogenesis of ASD and the related interventions.Entities:
Keywords: Autism spectrum disorders; Cortex; GABAergic neurons; Ion channels; Receptors
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Year: 2020 PMID： 32985165 PMCID： PMC8800729 DOI： 10.3785/j.issn.1008-9292.2020.08.10
Source DB: PubMed Journal: Zhejiang Da Xue Xue Bao Yi Xue Ban ISSN： 1008-9292