Literature DB >> 3298478

Activity of selected beta-lactam antibiotics against Mycobacterium leprae.

C C Shepard, R M Van Landingham, L L Walker, R C Good.   

Abstract

Twelve beta-lactam antibiotics were tested for activity against Mycobacterium leprae growing in the foot pads of mice. Two cephalosporins (7-aminocephalosporanic acid and cefuroxime) and one cephamycin (cefoxitin) showed significant activity against M. leprae, and one penicillin (mezlocillin) exerted possible growth-promoting activity. These results suggest that particular molecular structures may be required for activity against M. leprae.

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Year:  1987        PMID： 3298478

Source DB:  PubMed          Journal:  Int J Lepr Other Mycobact Dis        ISSN： 0148-916X


  5 in total

1.  Biochemical characterization of the 49 kDa penicillin-binding protein of Mycobacterium smegmatis.

Authors:  T Mukherjee; D Basu; S Mahapatra; C Goffin; J van Beeumen; J Basu
Journal:  Biochem J       Date:  1996-11-15       Impact factor: 3.857

2.  In vitro and in vivo activities of macrolides against Mycobacterium leprae.

Authors:  S G Franzblau; R C Hastings
Journal:  Antimicrob Agents Chemother       Date:  1988-12       Impact factor: 5.191

3.  Identification and overexpression in Escherichia coli of a Mycobacterium leprae gene, pon1, encoding a high-molecular-mass class A penicillin-binding protein, PBP1.

Authors:  J Basu; S Mahapatra; M Kundu; S Mukhopadhyay; M Nguyen-Distèche; P Dubois; B Joris; J Van Beeumen; S T Cole; P Chakrabarti; J M Ghuysen
Journal:  J Bacteriol       Date:  1996-03       Impact factor: 3.490

Review 4.  Leprosy.

Authors:  R C Hastings; T P Gillis; J L Krahenbuhl; S G Franzblau
Journal:  Clin Microbiol Rev       Date:  1988-07       Impact factor: 26.132

5.  Purification and partial characterization of a penicillin-binding protein from Mycobacterium smegmatis.

Authors:  J Basu; R Chattopadhyay; M Kundu; P Chakrabarti
Journal:  J Bacteriol       Date:  1992-07       Impact factor: 3.490
  5 in total

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