Tengfei Long1, Lingli Long2, Yaxiao Chen1, Yubin Li3, Ying Tuo4, Yue Hu2, Lingling Xie1, Gui He5, Wen Zhao3, Xiaofang Lu6, Zhongqiu Lin7. 1. Department of Gynaecology and Obstetrics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. 2. Translation Medicine Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China. 3. The Reproductive Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China. 4. Department of Pathology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China. 5. Cellular and Molecular Diagnostics Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. 6. Department of Pathology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China. 7. Department of Gynaecology and Obstetrics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. linzhongqiu0908@163.com.
Abstract
PURPOSE: Inflammation has been reported as a facilitator in cervical oncogenesis, but the correlation between inflammation and cytological abnormality remains uncertain. The aim of this study was to investigate the correlation between inflammation and cytological abnormality. METHODS: ThinPrep cytological test (TCT) was used to detect cervical cytological abnormalities and inflammation degrees of 46,255 women in this prospective cross-sectional study. Histopathological examination was used to define the cervical intraepithelial neoplasia (CIN) in patients with cervical cytological abnormalities. RESULTS: The study revealed that 8.87% (4102/46,255) of TCT results had cytological abnormalities. The 4102 included cases were classified as the case group, including atypical squamous cells (ASC), low-grade squamous intraepithelial lesions (LSIL) and high-grade squamous intraepithelial lesions (HSIL). Women with negative intraepithelial lesion or malignancy (NILM) were classified as the control group. About 88.83% (3644/4102) of women with cytological abnormalities showed inflammations. The rate of severe inflammation was significantly higher in the case group than the control group (23.86% vs. 2.0%, P = 0.000). Our results also showed that patients with severe inflammation had a significantly increasing incidence of cytological abnormality by 12.598 times and elevated the risk of HSIL by 756.47 times, compared to the inflammation negative group. CONCLUSION: Severe inflammation was positively related to HSIL. Patients with severe cervical inflammation should be given more follow-ups and regular examinations and treated more carefully than those with mild or no inflammation.
PURPOSE:Inflammation has been reported as a facilitator in cervical oncogenesis, but the correlation between inflammation and cytological abnormality remains uncertain. The aim of this study was to investigate the correlation between inflammation and cytological abnormality. METHODS: ThinPrep cytological test (TCT) was used to detect cervical cytological abnormalities and inflammation degrees of 46,255 women in this prospective cross-sectional study. Histopathological examination was used to define the cervical intraepithelial neoplasia (CIN) in patients with cervical cytological abnormalities. RESULTS: The study revealed that 8.87% (4102/46,255) of TCT results had cytological abnormalities. The 4102 included cases were classified as the case group, including atypical squamous cells (ASC), low-grade squamous intraepithelial lesions (LSIL) and high-grade squamous intraepithelial lesions (HSIL). Women with negative intraepithelial lesion or malignancy (NILM) were classified as the control group. About 88.83% (3644/4102) of women with cytological abnormalities showed inflammations. The rate of severe inflammation was significantly higher in the case group than the control group (23.86% vs. 2.0%, P = 0.000). Our results also showed that patients with severe inflammation had a significantly increasing incidence of cytological abnormality by 12.598 times and elevated the risk of HSIL by 756.47 times, compared to the inflammation negative group. CONCLUSION: Severe inflammation was positively related to HSIL. Patients with severe cervical inflammation should be given more follow-ups and regular examinations and treated more carefully than those with mild or no inflammation.
Authors: P E Castle; S L Hillier; L K Rabe; A Hildesheim; R Herrero; M C Bratti; M E Sherman; R D Burk; A C Rodriguez; M Alfaro; M L Hutchinson; J Morales; M Schiffman Journal: Cancer Epidemiol Biomarkers Prev Date: 2001-10 Impact factor: 4.254
Authors: L A Brinton; R F Hamman; G R Huggins; H F Lehman; R S Levine; K Mallin; J F Fraumeni Journal: J Natl Cancer Inst Date: 1987-07 Impact factor: 13.506
Authors: Akiko Kobayashi; Ruth M Greenblatt; Kathryn Anastos; Howard Minkoff; Leslie S Massad; Mary Young; Alexandra M Levine; Teresa M Darragh; Vivian Weinberg; Karen K Smith-McCune Journal: Cancer Res Date: 2004-09-15 Impact factor: 12.701