| Literature DB >> 32980412 |
Kandasamy Saravanakumar1, Arokia Vijaya Anand Mariadoss1, Anbazhagan Sathiyaseelan1, Myeong-Hyeon Wang2.
Abstract
The present work synthesized nano-chitosan capped gold nanoparticles (CS-AuNPs) and tested its bioactivities. The fourier-transform infrared spectroscopy (FTIR) exhibited glucosamine group revealed the capping of chitosan in CS-AuNPs. The X-ray photoelectron spectroscopy (XPS) demonstrated the peaks at 84.49 eV and 88.49 eV was corresponding to gold. The dynamic light scattering (DLS) analysis indicated the size of 98.14 ± 6.62 nm, poly dispersion index (PDI) of 0.232 and zeta potential of 46.8 ± 2.07 mV for CS-AuNPs. The CS-AuNPs was exhibited the higher antioxidant, antibacterial and diabetes related enzyme inhibitory activities than that in CSNPs. The 50% of LN229 cell death was occurred through the treatment of 218.75 μg. mL-1 and 500 μg. mL-1 of CS-AuNPs and CSNPs respectively. The inhibitory concentration (IC50) of CS-AuNPs showed higher cytotoxicity in LN229 via cellular damage, reactive oxygen species (ROS), and arresting about 42.33% cells in the G1 phase. These results proved the multifunctional bioactive properties of CS-AuNPs.Entities:
Keywords: Antibacterial; Antidiabetes; Antioxidant; Bioactivities; Chitosan; Cytotoxicity
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Year: 2020 PMID： 32980412 DOI： 10.1016/j.ijbiomac.2020.09.177
Source DB: PubMed Journal: Int J Biol Macromol ISSN： 0141-8130 Impact factor: 6.953