Literature DB >> 32979383

Routine Early Antibiotic Use in SymptOmatic Preterm Neonates: A Pilot Randomized Controlled Trial.

J Lauren Ruoss1, Catalina Bazacliu2, Jordan T Russell3, Diomel de la Cruz2, Nan Li2, Matthew J Gurka4, Stephanie L Filipp4, Richard A Polin5, Eric W Triplett3, Josef Neu2.   

Abstract

We enrolled 98 infants (gestational age <33 weeks) in a pilot randomized trial of antibiotics vs no antibiotics; 55 were randomized (lower maternal infectious risk; symptoms expected for gestation). Adverse events did not differ significantly between the randomization arms. This trial establishes a framework for a larger multicentered trial.
Copyright © 2020 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  dysbiosis; infants; microbiome; sepsis

Mesh：

Substances：

Year:  2020        PMID： 32979383      PMCID： PMC8958904          DOI： 10.1016/j.jpeds.2020.09.056

Source DB:  PubMed          Journal:  J Pediatr        ISSN： 0022-3476            Impact factor:   4.406


  21 in total

Review 1.  Pathogenesis of NEC: Impact of an altered intestinal microbiome.

Authors:  Josef Neu; Mohan Pammi
Journal:  Semin Perinatol       Date:  2016-12-13       Impact factor: 3.300

2.  The emergence of preclinical studies on the role of the microbiome in lung development and experimental animal models of bronchopulmonary dysplasia.

Authors:  Francisco Casado; Rory E Morty
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2020-01-22       Impact factor: 5.464

3.  Early-onset sepsis in very low birth weight neonates: a report from the National Institute of Child Health and Human Development Neonatal Research Network.

Authors:  B J Stoll; T Gordon; S B Korones; S Shankaran; J E Tyson; C R Bauer; A A Fanaroff; J A Lemons; E F Donovan; W Oh; D K Stevenson; R A Ehrenkranz; L A Papile; J Verter; L L Wright
Journal:  J Pediatr       Date:  1996-07       Impact factor: 4.406

Review 4.  Normal neonatal microbiome variation in relation to environmental factors, infection and allergy.

Authors:  Juliette C Madan; Shohreh F Farzan; Patricia L Hibberd; Margaret R Karagas
Journal:  Curr Opin Pediatr       Date:  2012-12       Impact factor: 2.856

5.  Sepsis from the gut: the enteric habitat of bacteria that cause late-onset neonatal bloodstream infections.

Authors:  Mike A Carl; I Malick Ndao; A Cody Springman; Shannon D Manning; James R Johnson; Brian D Johnston; Carey-Ann D Burnham; Erica Sodergren Weinstock; George M Weinstock; Todd N Wylie; Makedonka Mitreva; Sahar Abubucker; Yanjiao Zhou; Harold J Stevens; Carla Hall-Moore; Samuel Julian; Nurmohammad Shaikh; Barbara B Warner; Phillip I Tarr
Journal:  Clin Infect Dis       Date:  2014-03-18       Impact factor: 9.079

Review 6.  Intestinal dysbiosis in preterm infants preceding necrotizing enterocolitis: a systematic review and meta-analysis.

Authors:  Mohan Pammi; Julia Cope; Phillip I Tarr; Barbara B Warner; Ardythe L Morrow; Volker Mai; Katherine E Gregory; J Simon Kroll; Valerie McMurtry; Michael J Ferris; Lars Engstrand; Helene Engstrand Lilja; Emily B Hollister; James Versalovic; Josef Neu
Journal:  Microbiome       Date:  2017-03-09       Impact factor: 14.650

7.  Empirical antibiotic treatment and the risk of necrotizing enterocolitis and death in very low birth weight neonates.

Authors:  Eman A Abdel Ghany; Aliaa A Ali
Journal:  Ann Saudi Med       Date:  2012 Sep-Oct       Impact factor: 1.526

8.  A neonatal sequential organ failure assessment score predicts mortality to late-onset sepsis in preterm very low birth weight infants.

Authors:  James L Wynn; Richard A Polin
Journal:  Pediatr Res       Date:  2019-08-08       Impact factor: 3.756

Review 9.  Gut and Lung Microbiota in Preterm Infants: Immunological Modulation and Implication in Neonatal Outcomes.

Authors:  Chiara Tirone; Lucilla Pezza; Angela Paladini; Milena Tana; Claudia Aurilia; Alessandra Lio; Silvia D'Ippolito; Chiara Tersigni; Brunella Posteraro; Maurizio Sanguinetti; Nicoletta Di Simone; Giovanni Vento
Journal:  Front Immunol       Date:  2019-12-12       Impact factor: 7.561

10.  Distortions in development of intestinal microbiota associated with late onset sepsis in preterm infants.

Authors:  Volker Mai; Roberto Murgas Torrazza; Maria Ukhanova; Xiaoyu Wang; Yijun Sun; Nan Li; Jonathan Shuster; Renu Sharma; Mark Lawrence Hudak; Josef Neu
Journal:  PLoS One       Date:  2013-01-14       Impact factor: 3.240
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  3 in total

1.  Antibiotics and the developing intestinal microbiome, metabolome and inflammatory environment in a randomized trial of preterm infants.

Authors:  Jordan T Russell; J Lauren Ruoss; Diomel de la Cruz; Nan Li; Catalina Bazacliu; Laura Patton; Kelley Lobean McKinley; Timothy J Garrett; Richard A Polin; Eric W Triplett; Josef Neu
Journal:  Sci Rep       Date:  2021-01-21       Impact factor: 4.379

2.  The Diversity of the Intestinal Flora Disturbed After Feeding Intolerance Recovery in Preterm Twins.

Authors:  Ying Li; Chunhong Jia; Xiaojun Lin; Lili Lin; Lizhen Li; Xi Fan; Xiaoxia Huang; Zhanyuan Xu; Huixin Wang; Fan Wu; Guosheng Liu
Journal:  Front Pediatr       Date:  2021-03-10       Impact factor: 3.418

3.  Bacteroidota and Lachnospiraceae integration into the gut microbiome at key time points in early life are linked to infant neurodevelopment.

Authors:  Kaitlyn Oliphant; Mehneez Ali; Mark D'Souza; Patrick D Hughes; Dinanath Sulakhe; Annie Z Wang; Bingqing Xie; Rummanu Yeasin; Michael E Msall; Bree Andrews; Erika C Claud
Journal:  Gut Microbes       Date:  2021 Jan-Dec
  3 in total

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