Courtney D Thornburg1,2,3, Stephen W Erickson4, Grier P Page5, Erin A S Clark5, Margaret M DeAngelis5, M Elizabeth Hartnett6, Ricki F Goldstein7,6, John M Dagle8, Jeffrey C Murray8, Brenda B Poindexter9,10, Abhik Das11, C Michael Cotten7. 1. Department of Pediatrics, Duke University, Durham, NC, USA. cthornburg@rchsd.org. 2. Department of Pediatrics, University of California-San Diego, La Jolla, CA, USA. cthornburg@rchsd.org. 3. Hemophilia and Thrombosis Treatment Center, Rady Children's Hospital San Diego, San Diego, CA, USA. cthornburg@rchsd.org. 4. Social, Statistical and Environmental Sciences, RTI, Research Triangle Park, NC, USA. 5. Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT, USA. 6. Department of Pediatrics, University of Kentucky, Lexington, KY, USA. 7. Department of Pediatrics, Duke University, Durham, NC, USA. 8. Department of Pediatrics, University of Iowa, Iowa City, IA, USA. 9. Department of Pediatrics, University of Indiana, Indianapolis, IN, USA. 10. Department of Pediatrics, University of Cincinnati, Cincinnati, OH, USA. 11. Hemophilia and Thrombosis Treatment Center, Rady Children's Hospital San Diego, San Diego, CA, USA.
Abstract
OBJECTIVE: To test associations between grades 3 or 4 (severe) intraventricular hemorrhage (IVH) and single nucleotide polymorphisms (SNPs) associated with coagulation, inflammation, angiogenesis, and organ development in an exploratory study. STUDY DESIGN: Extremely low-birthweight (ELBW) infants enrolled in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network's (NRN) Cytokines Study were included if they had cranial ultrasound (CUS) and genotyping data available in the NRN Anonymized DNA Repository and Database. Associations between SNPs and IVH severity were tested with multivariable logistic regression analysis. RESULT: One hundred thirty-nine infants with severe IVH and 687 infants with grade 1 or 0 IVH were included. One thousand two hundred seventy-nine SNPs were genotyped. Thirteen were preliminarily associated with severe IVH including five related to central nervous system (CNS) neuronal and neurovascular development. CONCLUSION: Genetic variants for CNS neuronal and neurovascular development may be associated with severe IVH in premature infants.
OBJECTIVE: To test associations between grades 3 or 4 (severe) intraventricular hemorrhage (IVH) and single nucleotide polymorphisms (SNPs) associated with coagulation, inflammation, angiogenesis, and organ development in an exploratory study. STUDY DESIGN: Extremely low-birthweight (ELBW) infants enrolled in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network's (NRN) Cytokines Study were included if they had cranial ultrasound (CUS) and genotyping data available in the NRN Anonymized DNA Repository and Database. Associations between SNPs and IVH severity were tested with multivariable logistic regression analysis. RESULT: One hundred thirty-nine infants with severe IVH and 687 infants with grade 1 or 0 IVH were included. One thousand two hundred seventy-nine SNPs were genotyped. Thirteen were preliminarily associated with severe IVH including five related to central nervous system (CNS) neuronal and neurovascular development. CONCLUSION: Genetic variants for CNS neuronal and neurovascular development may be associated with severe IVH in premature infants.
Authors: G Ken-Dror; F Drenos; S E Humphries; P J Talmud; A D Hingorani; M Kivimäki; M Kumari; K A Bauer; J H Morrissey; H A Ireland Journal: J Thromb Haemost Date: 2010-11 Impact factor: 5.824