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Literature DB >> 3297784

Transcriptional enhancer activity in the variable tandem repeat DNA sequence downstream of the human Ha-ras 1 gene.

Abstract

A short term transfection technique using the chloramphenicol acetyltransferase gene as an assay system has been employed to examine the presence of transcriptional regulatory sequences within the variable tandem repeat (VTR) DNA sequence located downstream of the human Ha-ras1 gene. Here we find that the VTR sequences possess an endogenous enhancer activity of both the normal and the T24 mutant Ha-ras1 gene.

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Year: 1987 PMID： 3297784 DOI： 10.1016/0014-5793(87)81014-1

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

16 in total

1. Minisatellite alterations in ZRT1 mutants occur via RAD52-dependent and RAD52-independent mechanisms in quiescent stationary phase yeast cells.

Authors: Maire K Kelly; Bonnie Alver; David T Kirkpatrick
Journal: DNA Repair (Amst) Date: 2011-04-22

2. Length and sequence heterozygosity differentially affect HRAS1 minisatellite stability during meiosis in yeast.

Authors: Peter A Jauert; David T Kirkpatrick
Journal: Genetics Date: 2005-04-16 Impact factor: 4.562

3. Members of the rel/NF-kappa B family of transcriptional regulatory proteins bind the HRAS1 minisatellite DNA sequence.

Authors: W L Trepicchio; T G Krontiris
Journal: Nucleic Acids Res Date: 1992-05-25 Impact factor: 16.971

4. Allele-specific deletion in exon I of the HRAS1 gene.

Authors: A Kasperczyk; B A Mermer; D R Parkinson; J A Lonergan; T G Krontiris
Journal: Am J Hum Genet Date: 1989-11 Impact factor: 11.025

5. New approach for isolation of VNTR markers.

Authors: Y Nakamura; M Carlson; K Krapcho; M Kanamori; R White
Journal: Am J Hum Genet Date: 1988-12 Impact factor: 11.025

6. An upstream region of the mouse ZP3 gene directs expression of firefly luciferase specifically to growing oocytes in transgenic mice.

Authors: S A Lira; R A Kinloch; S Mortillo; P M Wassarman
Journal: Proc Natl Acad Sci U S A Date: 1990-09 Impact factor: 11.205

Transcriptional enhancer activity in the variable tandem repeat DNA sequence downstream of the human Ha-ras 1 gene.

1. Minisatellite alterations in ZRT1 mutants occur via RAD52-dependent and RAD52-independent mechanisms in quiescent stationary phase yeast cells.

2. Length and sequence heterozygosity differentially affect HRAS1 minisatellite stability during meiosis in yeast.

3. Members of the rel/NF-kappa B family of transcriptional regulatory proteins bind the HRAS1 minisatellite DNA sequence.

4. Allele-specific deletion in exon I of the HRAS1 gene.

5. New approach for isolation of VNTR markers.

6. An upstream region of the mouse ZP3 gene directs expression of firefly luciferase specifically to growing oocytes in transgenic mice.

7. Distribution of Ha-ras alleles in patients with colorectal cancer and Crohn's disease.

8. Loss of allelic heterozygosity at the harvey ras locus in human oral carcinomas.

9. Ha-ras rare alleles in breast cancer susceptibility.

10. Analysis of Ha-ras 1 allele frequencies in hereditary non-polyposis colorectal cancer.