| Literature DB >> 3297714 |
M E Gore, C A Hills, Z H Siddik, J P Sloane, A R Winkley, I E Smith, J L Millar.
Abstract
A dose of 170 mg/kg of carboplatin is lethal in mice, death occurring through bone marrow failure. This lethality can be avoided by giving the animals 200 mg/kg cyclophosphamide 1 or 2 days before this dose of carboplatin. The improved normal tissue tolerance cannot be explained by altered pharmacokinetics of carboplatin. Increased survival appears to be associated with a more rapid regeneration of the haemopoietic stem cells. Tumour tissue is not protected in the same way and thus a therapeutic gain can be achieved using this protocol.Entities:
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Year: 1987 PMID： 3297714 DOI： 10.1016/0277-5379(87)90422-6
Source DB: PubMed Journal: Eur J Cancer Clin Oncol ISSN： 0277-5379