| Literature DB >> 32976988 |
Omar Hikmat1, Bente Johanne Vederhus2, Merete Roineland Benestad3, Ida Malen E Engeset4, Claus Klingenberg5, Magnhild Rasmussen6, Chantal Me Tallaksen7, Eylert Brodtkorb8, Irene Bircow Elgen9, Laurence A Bindoff10.
Abstract
We aimed to assess the impact of POLG disease on mental health and quality of life in 15 patients using the Symptom Checklist-90-R (SCL-90-R) and Short-Form 36 Health Survey (RAND-36). We found increased scores in all nine subscales of SCL-90-R, particularly phobic anxiety, depression and somatization. Further, patients reported considerably lower scores in all RAND-36 domains. This study revealed a global decline in mental health and poor quality of life in patients with POLG disease and highlights the need for increased awareness and systematic assessment in order to improve their quality of life and mental health.Entities:
Keywords: Epilepsy; Mental health; Mitochondrial disease; POLG; Psychological distress; Quality of life
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Year: 2020 PMID： 32976988 DOI： 10.1016/j.mito.2020.09.005
Source DB: PubMed Journal: Mitochondrion ISSN： 1567-7249 Impact factor: 4.160