An Energy-Efficient Optically-Enhanced Highly-Linear Implantable Wirelessly-Powered Bidirectional Optogenetic Neuro-Stimulator.

This paper presents an energy-efficient mm-scale self-contained bidirectional optogenetic neuro-stimulator, which employs a novel highly-linear μLED driving circuit architecture as well as inkjet-printed custom-designed optical μlenses for light directivity enhancement. The proposed current-mode μLED driver performs linear control of optical stimulation for the entire target range ( 10 mA) while requiring the smallest reported headroom, yielding a significant boost in the energy conversion efficiency. A 30.46× improvement in the power delivery efficiency to the target tissue is achieved by employing a pair of printed optical μlenses. The fabricated SoC also integrates two recording channels for LFP recording and digitization, as well as power management blocks. A micro-coil is also embedded on the chip to receive inductive power and our experimental results show a PTE of 2.24 % for the wireless link. The self-contained system including the μLEDs, μlenses and the capacitors required by the power management blocks is sized 6 mm 3 and weighs 12.5 mg. Full experimental measurement results for electrical and optical circuitry as well as in vitro measurement results are reported.