Cell-contact and -architecture of malignant cells and their relationship to metastasis.

The interaction of metastatic cells with the host environment occurs, to a large extent, through the cell surface, and the cell cytoskeletal system controls the distribution and motility of cell surface receptors. During metastasis, tumor cells migrate from one organ to another, and the dynamic properties and mechanochemical deformability of disseminated cells play a central role in the process. The studies described here under suggest an interrelationship between the cytoskeleton and cell adhesion, which can control and augment the expression of the metastatic phenotype of neoplastic cells.