| Literature DB >> 32972996 |
Paul Bastard1,2,3, Lindsey B Rosen4, Qian Zhang3, Eleftherios Michailidis5, Hans-Heinrich Hoffmann5, Yu Zhang4, Karim Dorgham6, Quentin Philippot7,2, Jérémie Rosain7,2, Vivien Béziat7,2,3, Steven M Holland4, Guy Gorochov6,8, Emmanuelle Jouanguy7,2,3, Charles M Rice5, Aurélie Cobat7,2,3, Luigi D Notarangelo4, Laurent Abel7,2,3, Helen C Su4, Jean-Laurent Casanova1,2,3,9,10, Jérémy Manry7,2, Elana Shaw4, Liis Haljasmägi11, Pärt Peterson11, Lazaro Lorenzo7,2, Lucy Bizien7,2, Sophie Trouillet-Assant12,13, Kerry Dobbs4, Adriana Almeida de Jesus4, Alexandre Belot13,14,15, Anne Kallaste16, Emilie Catherinot17, Yacine Tandjaoui-Lambiotte18, Jeremie Le Pen5, Gaspard Kerner7,2, Benedetta Bigio3, Yoann Seeleuthner7,2, Rui Yang3, Alexandre Bolze19, András N Spaan3,20, Ottavia M Delmonte4, Michael S Abers4, Alessandro Aiuti21, Giorgio Casari21, Vito Lampasona21, Lorenzo Piemonti21, Fabio Ciceri21, Kaya Bilguvar22, Richard P Lifton22,23,24, Marc Vasse25, David M Smadja26, Mélanie Migaud7,2, Jérome Hadjadj27, Benjamin Terrier28, Darragh Duffy29, Lluis Quintana-Murci30,31, Diederik van de Beek32, Lucie Roussel33,34, Donald C Vinh33,34, Stuart G Tangye35,36, Filomeen Haerynck37, David Dalmau38, Javier Martinez-Picado39,40,41, Petter Brodin42,43, Michel C Nussenzweig44,9, Stéphanie Boisson-Dupuis7,2,3, Carlos Rodríguez-Gallego45,46, Guillaume Vogt47, Trine H Mogensen48,49, Andrew J Oler50, Jingwen Gu50, Peter D Burbelo51, Jeffrey I Cohen52, Andrea Biondi53, Laura Rachele Bettini53, Mariella D'Angio53, Paolo Bonfanti54, Patrick Rossignol55, Julien Mayaux56, Frédéric Rieux-Laucat27, Eystein S Husebye57,58,59, Francesca Fusco60, Matilde Valeria Ursini60, Luisa Imberti61, Alessandra Sottini61, Simone Paghera61, Eugenia Quiros-Roldan62, Camillo Rossi63, Riccardo Castagnoli64, Daniela Montagna65,66, Amelia Licari64, Gian Luigi Marseglia64, Xavier Duval67,68,69,70,71, Jade Ghosn70,71, John S Tsang72,73, Raphaela Goldbach-Mansky4, Kai Kisand11, Michail S Lionakis4, Anne Puel7,2,3, Shen-Ying Zhang7,2,3.
Abstract
Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-ω (IFN-ω) (13 patients), against the 13 types of IFN-α (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men.Entities:
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Year: 2020 PMID： 32972996 PMCID： PMC7857397 DOI： 10.1126/science.abd4585
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 63.714